黏连蛋白——弥合基因转录、基因组稳定性与人类疾病之间的差距。
Cohesin - bridging the gap among gene transcription, genome stability, and human diseases.
作者信息
Di Nardo Maddalena, Musio Antonio
机构信息
Institute for Biomedical Technologies (ITB), National Research Council (CNR), Pisa, Italy.
出版信息
FEBS Lett. 2025 Jan;599(2):190-208. doi: 10.1002/1873-3468.14949. Epub 2024 Jun 9.
PMID:38852996
Abstract
The intricate landscape of cellular processes governing gene transcription, chromatin organization, and genome stability is a fascinating field of study. A key player in maintaining this delicate equilibrium is the cohesin complex, a molecular machine with multifaceted roles. This review presents an in-depth exploration of these intricate connections and their significant impact on various human diseases.
摘要
控制基因转录、染色质组织和基因组稳定性的复杂细胞过程景观是一个引人入胜的研究领域。维持这种微妙平衡的关键因素是黏连蛋白复合体，这是一种具有多方面作用的分子机器。本综述深入探讨了这些复杂的联系及其对各种人类疾病的重大影响。
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