Rashad Essam, Moazam Mustafa M, Chaudhry Raheel, El Eraky Noha, Mirza Muhammad Sohail S, Nazmin Farhana
Hospital Medicine, Parkview Regional Medical Center, Fort Wayne, USA.
Psychiatry, Texas Tech University Health Sciences Center El Paso, El Paso, USA.
Cureus. 2024 May 10;16(5):e60049. doi: 10.7759/cureus.60049. eCollection 2024 May.
Autoimmune hepatitis (AIH) is a hepatocellular disorder thought to be caused by an immune system that cannot tolerate autoantigens specific to hepatocytes. This study aims to evaluate the efficacy of using corticosteroids (prednisolone and azathioprine) as a combination therapy in treating AIH. This study aims to synthesize and analyze existing evidence to inform clinical practices concerning the overall clinical efficacy of this treatment approach in managing AIH. A comprehensive search was conducted across multiple online databases and search engines, including PubMed, Google Scholar, ScienceDirect, Medline, and Embase. RevMan 5.4 software was used for meta-analysis, with forest plots created for each outcome. Thirteen studies were included in this systematic review and meta-analysis. The results indicate that the combination of prednisolone and azathioprine for treating AIH leads to less recurrence and better disease control.
自身免疫性肝炎（AIH）是一种肝细胞疾病，被认为是由无法耐受肝细胞特异性自身抗原的免疫系统引起的。本研究旨在评估使用皮质类固醇（泼尼松龙和硫唑嘌呤）联合治疗AIH的疗效。本研究旨在综合和分析现有证据，为临床实践提供有关这种治疗方法在管理AIH方面的总体临床疗效的信息。在多个在线数据库和搜索引擎中进行了全面搜索，包括PubMed、谷歌学术、ScienceDirect、Medline和Embase。使用RevMan 5.4软件进行荟萃分析，并为每个结果创建森林图。本系统评价和荟萃分析纳入了13项研究。结果表明，泼尼松龙和硫唑嘌呤联合治疗AIH可减少复发并更好地控制疾病。
