Zeng Rui, Chen Jun, Wang Yimin, Liu Qiang
Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
SAGE Open Med. 2024 Jun 7;12:20503121241245003. doi: 10.1177/20503121241245003. eCollection 2024.
Functional electrical stimulation is important for the rehabilitation of patients with chronic heart failure. This meta-analysis of randomized controlled trials compared the efficacy of functional electrical stimulation versus conventional exercise training or placebo in patients with chronic heart failure.
Studies were searched through PubMed, Embase, and the Cochrane Library databases up to 1 November 2023. The outcomes were cardiopulmonary function index (6-minute walking distance), peak oxygen consumption, and Minnesota Heart Failure Life Questionnaire quality of life scores. A subgroup analysis was conducted according to the ejection fraction. The 95% confidence interval and mean difference represented the outcome of the effect size.
Seventeen studies involving 732 participants were included. Compared with the control, functional electrical stimulation significantly improved peak oxygen consumption (MD = 2.84 ml/kg/min, 95% Cl: 1.99-3.68 ml/kg/min), increased 6-minute walking distance (MD = 49.52 m, 95% Cl: 22.61-76.43 m), and improved the life quality scores (MD = -12.86, 95% Cl: -17.48 to -7.88). Compared with functional electrical stimulation, exercise training also improved peak oxygen consumption (MD = -0.94 ml/kg/min, 95% Cl: -1.36 to -0.52 ml/kg/min), and the quality of life (QoL, MD = 0.66, 95% Cl: 0.34-0.98, < 0.05, = 38%), but the result of 6-minute walking distance (MD = -6.97 m, 95% Cl: -18.32 to -4.38 m) did not show a difference. Further subgroup analysis showed that outcomes including the above, significantly improved under the functional electrical stimulationfor both HF patients with reduced ejection fraction and HF patients with preserved ejection fraction patients, but difference is insignificant of the results between groups of aerobic exercise and functional electrical stimulationacted on patients with HF patients with reduced ejection fraction.
Our study demonstrates that compared with placebo, functional electrical stimulation benefits the patients with chronic heart failure on cardiopulmonary function and quality of life. Furthermore, HF patients with reduced ejection fraction patients benefit more from functional electrical stimulation than HF patients with reduced ejection fraction patients. Therefore, functional electrical stimulation is a promising complementary therapy for patients with chronic heart failure.
功能性电刺激对慢性心力衰竭患者的康复很重要。这项随机对照试验的荟萃分析比较了功能性电刺激与传统运动训练或安慰剂对慢性心力衰竭患者的疗效。
通过检索截至2023年11月1日的PubMed、Embase和Cochrane图书馆数据库来查找研究。结果指标为心肺功能指数（6分钟步行距离）、峰值耗氧量和明尼苏达心力衰竭生活质量问卷得分。根据射血分数进行亚组分析。95%置信区间和平均差代表效应量的结果。
纳入了17项研究，共732名参与者。与对照组相比，功能性电刺激显著提高了峰值耗氧量（MD = 2.84 ml/kg/min，95% Cl：1.99 - 3.68 ml/kg/min），增加了6分钟步行距离（MD = 49.52 m，95% Cl：22.61 - 76.43 m），并改善了生活质量得分（MD = -12.86，95% Cl：-17.48至-7.88）。与功能性电刺激相比，运动训练也改善了峰值耗氧量（MD = -0.94 ml/kg/min，95% Cl：-1.36至-0.52 ml/kg/min）和生活质量（QoL，MD = 0.66，95% Cl：0.34 - 0.98，P < 0.
