Ahmad Suhaib Js, Degiannis Jason R, Borucki Joseph, Pouwels Sjaak, Rawaf David Laith, Lala Anil, Whiteley Graham S, Head Marion, Simpson Angharad, Archid Rami, Ahmed Ahmed R, Soler J Agustin, Wichmann Doerte, Thangavelu Mohanarangam, Abdulmajed Mohamed, Elmousili Mahmoud, Lin Yan-Ren, Gelber Edgar, Exadaktylos Aristomenis K
Betsi Cadwaladr University Health Board Department of General Surgery Wales UK.
University Hospital of Bern Department of Emergency Medicine Inselspital Switzerland.
J Acute Med. 2024 Jun 1;14(2):51-60. doi: 10.6705/j.jacme.202406_14(2).0001.
Since late 2019, the global community has been gripped by the uncertainty surrounding the SARS-CoV-2 pandemic. In November 2021, the emergence of the Omicron variant in South Africa added a new dimension. This study aims to assess the disease's severity and determine the extent to which vaccinations contribute to reducing mortality rates.
A systematic review and meta-analysis of the epidemiological implications of the omicron variant of SARS-CoV-2 were performed, incorporating an analysis of articles from November 2021that address mortality rates.
The analysis incorporated data from 3,214,869 patients infected with omicron, as presented in 270 articles. A total of 6,782 deaths from the virus were recorded (0.21%). In the analysed articles, the pooled mortality rate was 0.003 and the pooled in-house mortality rate was 0.036. Vaccination is an effective step in preventing death (odds ratio: 0.391, < 0.01).
The mortality rates for the omicron variant are lower than for the preceding delta variant. mRNA vaccination affords secure and effective protection against severe disease and death from omicron.
自2019年末以来，全球社会一直笼罩在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行的不确定性之中。2021年11月，南非出现的奥密克戎变异株又增添了新的情况。本研究旨在评估该疾病的严重程度，并确定疫苗接种在降低死亡率方面的作用程度。
对SARS-CoV-2奥密克戎变异株的流行病学影响进行了系统评价和荟萃分析，纳入了对2021年11月以来涉及死亡率的文章的分析。
分析纳入了270篇文章中3,214,869例感染奥密克戎患者的数据。该病毒共造成6,782人死亡（0.21%）。在分析的文章中，汇总死亡率为0.003，汇总院内死亡率为0.036。接种疫苗是预防死亡的有效措施（优势比：0.391，P < 0.01）。
奥密克戎变异株的死亡率低于之前的德尔塔变异株。信使核糖核酸（mRNA）疫苗可为预防奥密克戎导致的重症疾病和死亡提供安全有效的保护。
