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结直肠癌转移至甲状腺:一例报告。

Colorectal cancer metastases to the thyroid gland: A case report.

作者信息

Ciriano Hernández Patricia, Martínez Pinedo Carlos, Calcerrada Alises Enrique, García Santos Esther, Sánchez García Susana, Picón Rodríguez Rafael, Jiménez Higuera Elisa, Sánchez Peláez Daniel, Herrera Montoro Violeta, Martín Fernández Jesús

机构信息

Department of Surgery, Hospital General Universitario de Ciudad Real, Ciudad Real 13005, Spain.

Department of Pathology, Hospital General Universitario de Ciudad Real, Ciudad Real 13005, Castilla La Mancha, Spain.

出版信息

World J Gastrointest Surg. 2020 Mar 27;12(3):116-122. doi: 10.4240/wjgs.v12.i3.116.

DOI:10.4240/wjgs.v12.i3.116
PMID:32218894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7061239/
Abstract

BACKGROUND

Secondary malignancies of the thyroid gland are a rare finding in clinical practice. In addition, colorectal metastasis to the thyroid (CMT) is even more infrequently diagnosed. The source of the primary tumor follows demographic and ethnic patterns, which reflects the most prevalent malignancies in the different populations. Colorectal cancer is one of the most common types of cancer worldwide; nevertheless, CMT is infrequently diagnosed. Most of them are identified during the follow-up of gastrointestinal primary malignancies. Due to the improvement of image techniques, oncological treatment, and follow-up, survival and consequent diagnosis of metastatic disease are more frequent. Those facts make this entity a diagnostic and therapeutic challenge, due to the lack of information and the difficulties performing clinical trials and research.

CASE SUMMARY

Here, we present a case report of a patient diagnosed with CMT of adenocarcinoma of the rectum evidenced during follow-up, 4 years after neoadjuvant chemoradiotherapy, who had subsequent curative surgical treatment of the primary tumor and inter-current lung bilateral metastases.

CONCLUSION

Thyroid metastases of extra-thyroid origin are an uncommon finding, even rarer in cases of CMT. The diagnostic process, as well as survival of oncologic patients is improving, and consequently the number of metastases to the thyroid gland is increasing.

摘要

背景

甲状腺继发性恶性肿瘤在临床实践中较为罕见。此外,结直肠癌转移至甲状腺(CMT)的诊断更为罕见。原发肿瘤的来源遵循人口统计学和种族模式,这反映了不同人群中最常见的恶性肿瘤。结直肠癌是全球最常见的癌症类型之一;然而,CMT很少被诊断出来。大多数病例是在胃肠道原发性恶性肿瘤的随访过程中发现的。由于影像技术、肿瘤治疗和随访的进步,转移性疾病的生存率和后续诊断更为常见。由于缺乏信息以及开展临床试验和研究存在困难,这些情况使得该疾病成为诊断和治疗的挑战。

病例摘要

在此,我们报告一例患者,该患者在新辅助放化疗4年后的随访中被诊断为直肠腺癌CMT,随后对原发肿瘤进行了根治性手术治疗,并出现了双侧肺转移。

结论

甲状腺外源性转移至甲状腺是一种罕见的情况,在CMT病例中更为罕见。肿瘤患者的诊断过程以及生存率正在改善,因此转移至甲状腺的病例数量正在增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c202/7061239/a5a7cd475ed0/WJGS-12-116-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c202/7061239/b729254a7b08/WJGS-12-116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c202/7061239/c55c51e749fb/WJGS-12-116-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c202/7061239/270ba6d06fe8/WJGS-12-116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c202/7061239/ce608c7790f6/WJGS-12-116-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c202/7061239/a5a7cd475ed0/WJGS-12-116-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c202/7061239/b729254a7b08/WJGS-12-116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c202/7061239/c55c51e749fb/WJGS-12-116-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c202/7061239/270ba6d06fe8/WJGS-12-116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c202/7061239/ce608c7790f6/WJGS-12-116-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c202/7061239/a5a7cd475ed0/WJGS-12-116-g005.jpg

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本文引用的文献

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Acta Cytol. 2018;62(5-6):443-449. doi: 10.1159/000490367. Epub 2018 Jul 13.
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Colon cancer metastasis to the thyroid gland: A case report.结肠癌转移至甲状腺:一例报告。
二次甲状腺恶性肿瘤甲状腺切除术的疗效:单中心经验
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A Rare Case of Thyroid Metastasis From Colorectal Cancer: Diagnostic and Therapeutic Challenges.一例罕见的结直肠癌甲状腺转移病例:诊断与治疗挑战
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Colorectal cancer metastases in thyroid: case report and literature review.甲状腺中的结直肠癌转移:病例报告及文献综述
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