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在 COVID-19 危机期间,埃塞俄比亚西北部巴希尔达市公共卫生机构接受服务的 HIV 感染者中,成人对抗逆转录病毒疗法的坚持及其决定因素。

Adherence to antiretroviral therapy and determining factors in adults living with HIV receiving services at public health facilities amidst the COVID-19 crisis in Bahir Dar city, Northwest Ethiopia.

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Science, Bahir Dar University, Bahir Dar, Ethiopia.

HIV/AIDS Prevention Treatment and Care, Amhara Regional State Health Bureau, Bahir Dar, Ethiopia.

出版信息

Front Public Health. 2024 Apr 19;12:1380055. doi: 10.3389/fpubh.2024.1380055. eCollection 2024.

Abstract

BACKGROUND

The COVID-19 pandemic has presented new challenges to adhering to ART, and its influence on adherence and related factors has not been thoroughly studied. This study examines ART adherence and its associated factors during the COVID-19 pandemic.

METHODS

A cross-sectional study was conducted on HIV-positive individuals receiving care and treatment in public health facilities. A total of 612 participants were selected using a multi-stage sampling procedure. Data were collected through interviewer-administered questionnaires and chart reviews. We used Epi-data for data entry and Stata for data analysis.

RESULTS

Good adherence to antiretroviral therapy in this study was 76.5% (95% CI, 72.9, 79.7). Divorced marital status (AOR = 0.45,95%CI:0.22,0.90), regular follow-up (AOR = 3.01,95%CI:1.81,5.01), adherence counseling and information in the context of COVID-19 pandemic (AOR = 2.57,95%CI:1.63,4.08), and knowledge about ART (AOR = 1.81,95%CI:1.11,2.94) were significantly associated with adherence to antiretroviral therapy.

CONCLUSION

The observed adherence rate in this study was lower than the World Health Organization recommendation and previous studies. The study highlighted the importance of addressing adherence to ART among HIV-positive adults during the COVID-19 pandemic and other upcoming emerging and reemerging outbreaks. Strategies to improve adherence should consider factors such as marital status, regular follow-up, provision of counseling and information, and enhancing knowledge about ART.

摘要

背景

COVID-19 大流行给坚持接受抗逆转录病毒治疗(ART)带来了新的挑战,其对坚持治疗的影响及其相关因素尚未得到彻底研究。本研究旨在探讨 COVID-19 大流行期间 ART 的坚持情况及其相关因素。

方法

采用横断面研究方法,对在公立卫生机构接受护理和治疗的 HIV 阳性个体进行研究。采用多阶段抽样程序选择了 612 名参与者。通过访谈员管理的问卷和病历回顾收集数据。我们使用 Epi-data 进行数据录入,使用 Stata 进行数据分析。

结果

本研究中,抗逆转录病毒治疗的良好坚持率为 76.5%(95%CI,72.9,79.7)。离婚的婚姻状况(AOR=0.45,95%CI:0.22,0.90)、定期随访(AOR=3.01,95%CI:1.81,5.01)、在 COVID-19 大流行背景下提供的依从性咨询和信息(AOR=2.57,95%CI:1.63,4.08)以及对 ART 的了解(AOR=1.81,95%CI:1.11,2.94)与抗逆转录病毒治疗的依从性显著相关。

结论

本研究观察到的依从率低于世界卫生组织的建议和以前的研究。研究强调了在 COVID-19 大流行和其他即将出现的新发和再发疫情期间,关注 HIV 阳性成年人对 ART 的坚持性的重要性。提高依从性的策略应考虑婚姻状况、定期随访、提供咨询和信息以及增强对 ART 的了解等因素。

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