Li Huai-Yu, Yan Wei-Xin, Li Jia, Ye Jing, Wu Zhi-Guo, Hou Zheng-Kun, Chen Bin
Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, China.
Front Pharmacol. 2024 May 24;15:1403767. doi: 10.3389/fphar.2024.1403767. eCollection 2024.
Enteric glia are essential components of the enteric nervous system. Previously believed to have a passive structural function, mounting evidence now suggests that these cells are indispensable for maintaining gastrointestinal homeostasis and exert pivotal influences on both wellbeing and pathological conditions. This study aimed to investigate the global status, research hotspots, and future directions of enteric glia.
The literature on enteric glia research was acquired from the Web of Science Core Collection. VOSviewer software (v1.6.19) was employed to visually represent co-operation networks among countries, institutions, and authors. The co-occurrence analysis of keywords and co-citation analysis of references were conducted using CiteSpace (v6.1.R6). Simultaneously, cluster analysis and burst detection of keywords and references were performed.
A total of 514 publications from 36 countries were reviewed. The United States was identified as the most influential country. The top-ranked institutions were University of Nantes and Michigan State University. Michel Neunlist was the most cited author. "Purinergic signaling" was the largest co-cited reference cluster, while "enteric glial cells (EGCs)" was the cluster with the highest number of co-occurring keywords. As the keyword with the highest burst strength, Crohns disease was a hot topic in the early research on enteric glia. The burst detection of keywords revealed that inflammation, intestinal motility, and gut microbiota may be the research frontiers.
This study provides a comprehensive bibliometric analysis of enteric glia research. EGCs have emerged as a crucial link between neurons and immune cells, attracting significant research attention in neurogastroenterology. Their fundamental and translational studies on inflammation, intestinal motility, and gut microbiota may promote the treatment of some gastrointestinal and parenteral disorders.
肠神经胶质细胞是肠神经系统的重要组成部分。以前认为它们具有被动的结构功能，但现在越来越多的证据表明，这些细胞对于维持胃肠道稳态不可或缺，并且对健康和病理状况都有关键影响。本研究旨在调查肠神经胶质细胞的全球研究现状、热点及未来方向。
从科学网核心合集获取有关肠神经胶质细胞研究的文献。使用VOSviewer软件（v1.6.19）直观呈现国家、机构和作者之间的合作网络。使用CiteSpace（v6.1.R6）进行关键词共现分析和参考文献共被引分析。同时，对关键词和参考文献进行聚类分析和突现检测。
共审查了来自36个国家的514篇出版物。美国被确定为最具影响力的国家。排名靠前的机构是南特大学和密歇根州立大学。米歇尔·纽恩利斯特是被引用次数最多的作者。“嘌呤能信号传导”是最大的共被引参考文献聚类，而“肠神经胶质细胞（EGCs）”是共现关键词数量最多的聚类。作为突现强度最高的关键词，克罗恩病是肠神经胶质细胞早期研究中的一个热点话题。关键词突现检测表明，炎症、肠道蠕动和肠道微生物群可能是研究前沿。
本研究提供了对肠神经胶质细胞研究的全面文献计量分析。肠神经胶质细胞已成为神经元与免疫细胞之间的关键联系，在神经胃肠病学领域吸引了大量研究关注。它们在炎症、肠道蠕动和肠道微生物群方面的基础研究和转化研究可能会促进一些胃肠道和非胃肠道疾病的治疗。
