Lindgren U, Djupsjö H
Acta Orthop Scand. 1985 Feb;56(1):28-31. doi: 10.3109/17453678508992974.
Sixty-eight patients were studied during the day after hip replacement for arthrosis. No pain reliever was allowed within 4 h prior to initial assessment of pain. An injection of diclofenac 75 mg, pethidine 50 mg, or placebo was given intramuscularly, and a second injection was usually given after 3.5 h. Pain was recorded before and for 3 h after these injections. Ten patients in the placebo group demanded rescue drug because of insufficient pain relief. Four patients discontinued the study due to side effects: nausea (one patient in the placebo group) and somnolence or nausea (three patients in the pethidine group). Assessed both by visual analogue scale (VAS), and by the investigator's assessment, the diclofenac group had less pain than the pethidine and placebo groups. Side effects were least frequent in the diclofenac group. This study demonstrates that at the doses used here, compared with pethidine, diclofenac is more effective in relieving postoperative pain and has fewer side effects.
对68例因骨关节炎行髋关节置换术后的患者进行了日间研究。在首次评估疼痛前4小时内不允许使用任何止痛剂。肌肉注射75毫克双氯芬酸、50毫克哌替啶或安慰剂，通常在3.5小时后进行第二次注射。在这些注射前和注射后3小时记录疼痛情况。安慰剂组中有10名患者因疼痛缓解不足而要求使用急救药物。4名患者因副作用而退出研究：恶心（安慰剂组1名患者）和嗜睡或恶心（哌替啶组3名患者）。通过视觉模拟量表（VAS）和研究者评估，双氯芬酸组的疼痛程度低于哌替啶组和安慰剂组。双氯芬酸组的副作用最少。这项研究表明，在此处使用的剂量下，与哌替啶相比，双氯芬酸在缓解术后疼痛方面更有效，且副作用更少。
