轻度认知障碍可预测少肌症的发生：来自英国老龄化纵向研究的纵向分析。

Mild cognitive impairment predicts the onset of Sarcopenia: a longitudinal analysis from the English Longitudinal Study on Ageing.

机构信息

Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Via del Vespro, 141, 90127,, Palermo, Italy.

Faculty of Medicine and Surgery, Kore University of Enna, Enna, Italy.

出版信息

Aging Clin Exp Res. 2024 Jun 10;36(1):129. doi: 10.1007/s40520-024-02781-z.

DOI:10.1007/s40520-024-02781-z

PMID:38856870

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11164776/

Abstract

BACKGROUND

Mild cognitive impairment (MCI) and sarcopenia are two common conditions in older people. It is not widely known if MCI could predict the onset of sarcopenia. Therefore, we aimed to investigate whether MCI could predict the occurrence of sarcopenia in a population of older adults.

METHODS

In the ELSA (English Longitudinal Study on Ageing), MCI was defined as the absence of dementia, preserved functional capacity and low performance in three objective cognitive tests. Sarcopenia was diagnosed as having low handgrip strength and low skeletal muscle mass index during follow-up. The longitudinal association between MCI at the baseline and incident sarcopenia was assessed using a multivariable logistic regression model, reporting the data as adjusted odds ratios (OR) and 95% confidence intervals (95%CI).

RESULTS

3,106 participants (mean age of 63.1 years; 55.3% males) were included. People with MCI reported significantly lower mean handgrip strength values and Skeletal Mass Index (SMI), as well as a higher prevalence of obesity at baseline. At baseline, 729 people had MCI and during the ten years follow-up period, 12.1% of the initial population included had sarcopenia. On multivariate analysis, adjusted for 18 potential confounders, the presence of MCI (OR = 1.236; 95%CI: 1.090-1.596, p = 0.01) significantly predicted the onset of sarcopenia during follow-up.

CONCLUSION

The presence of MCI at baseline was associated with a higher incidence of sarcopenia at ten-years follow-up, demonstrating a likely role of MCI as a predictor of the onset of sarcopenia in older people.

摘要

背景

轻度认知障碍（MCI）和肌肉减少症是老年人中两种常见的疾病。目前尚不清楚 MCI 是否可以预测肌肉减少症的发生。因此，我们旨在调查 MCI 是否可以预测老年人群中肌肉减少症的发生。

方法

在 ELSA（英国老龄化纵向研究）中，MCI 被定义为无痴呆、功能保留和三项客观认知测试中表现不佳。在随访期间，肌肉减少症被诊断为握力低和骨骼肌质量指数低。使用多变量逻辑回归模型评估基线时 MCI 与新发肌肉减少症之间的纵向关联，报告数据为调整后的优势比（OR）和 95%置信区间（95%CI）。

结果

共纳入 3106 名参与者（平均年龄 63.1 岁，55.3%为男性）。患有 MCI 的人报告的平均握力值和骨骼肌质量指数（SMI）明显较低，并且在基线时肥胖的患病率更高。基线时，729 人患有 MCI，在 10 年随访期间，初始人群中有 12.1%患有肌肉减少症。在多变量分析中，调整了 18 个潜在混杂因素后，存在 MCI（OR=1.236；95%CI：1.090-1.596，p=0.01）显著预测了随访期间肌肉减少症的发生。