Childs J E, Korch G W, Smith G A, Terry A D, Leduc J W
Am J Trop Med Hyg. 1985 Mar;34(2):385-7. doi: 10.4269/ajtmh.1985.34.385.
Recent studies indicate that domestic rats (Rattus norvegicus) from harbor-side areas within port cities of the United States are infected with a Hantaan-like virus. The geographical distribution of seropositive rats may be extremely localized within these urban environments. We surveyed four widely separated residential sites distant from the harbor within Baltimore, Maryland, USA, to determine the geographical distribution and prevalence of antibody to Hantaan-like virus in rats from urban areas of high human population density. Captured rats were weighed and examined for sexual maturity to allow some estimation of age, and their sera were examined by indirect immunofluorescent antibody assay for antibody to Hantaan virus. Seropositive rats were found at all four sites within Baltimore. Increasing antibody prevalence and high titers were associated with increasing rat weight and sexual maturity. Our results show that infection of rats by a Hantaan-like virus is widespread in Baltimore. Antibody in rats may be due to infections acquired during maturation or the delayed seroconversion of rats infected prior to weaning.
最近的研究表明，美国港口城市港口周边地区的家鼠（褐家鼠）感染了一种汉坦病毒样病毒。在这些城市环境中，血清反应阳性大鼠的地理分布可能极为局限。我们在美国马里兰州巴尔的摩市远离港口的四个相距甚远的居民区进行了调查，以确定高人口密度城市地区大鼠中汉坦病毒样病毒抗体的地理分布和流行情况。对捕获的大鼠进行称重，并检查其性成熟情况以大致估算年龄，然后通过间接免疫荧光抗体试验检测它们的血清中是否存在汉坦病毒抗体。在巴尔的摩的所有四个地点都发现了血清反应阳性大鼠。抗体流行率的增加和高滴度与大鼠体重增加和性成熟有关。我们的结果表明，汉坦病毒样病毒对大鼠的感染在巴尔的摩广泛存在。大鼠体内的抗体可能是由于成熟过程中获得的感染，或者是断奶前感染的大鼠血清转化延迟所致。
