LeDuc J W, Smith G A, Childs J E, Pinheiro F P, Maiztegui J I, Niklasson B, Antoniades A, Robinson D M, Khin M, Shortridge K F
Bull World Health Organ. 1986;64(1):139-44.
A global serological survey of rodents was conducted to determine the distribution and prevalence of antibody to Hantaan-related viruses, which are the causative agents of haemorrhagic fever with renal syndrome (HFRS) in man. Over 1700 rodent sera from more than 20 sites worldwide were examined by immunofluorescent antibody assay. High-titred positive sera were further tested by plaque reduction neutralization tests with prototype Hantaan virus and urban rat-associated Hantaan-like virus. Antibody-positive rodents were found in most, but not all, sites sampled. The highest antibody prevalence rates were found in Baltimore, MD, USA and Bélem, Brazil, and Rattus norvegicus was the species most often found positive. Bandicota indica and B. bengalensis, species previously not recognized as hosts of hantaviruses, were also positive. Neutralization tests detected antibody in Rattus sera specific for urban rat-associated Hantaan-like virus, but failed to establish the specificity of antibody in Bandicota sera. These results indicate that Hantaan-related viruses exist beyond the currently recognized boundaries of HFRS in man and suggest that human HFRS-like disease might be occurring in other areas of the world where rodent-human contact is common.
开展了一项全球啮齿动物血清学调查，以确定与汉坦病毒相关病毒抗体的分布和流行情况，这些病毒是人类肾综合征出血热（HFRS）的病原体。通过免疫荧光抗体试验检测了来自全球20多个地点的1700多份啮齿动物血清。对高滴度阳性血清进一步用汉坦原型病毒和城市大鼠相关汉坦样病毒进行蚀斑减少中和试验。在大多数（但并非所有）采样地点都发现了抗体阳性的啮齿动物。抗体流行率最高的是美国马里兰州巴尔的摩和巴西贝伦，褐家鼠是最常呈阳性的物种。板齿鼠和孟加拉板齿鼠这两个以前未被确认为汉坦病毒宿主的物种也呈阳性。中和试验在褐家鼠血清中检测到了针对城市大鼠相关汉坦样病毒的特异性抗体，但未能确定板齿鼠血清中抗体的特异性。这些结果表明，与汉坦病毒相关的病毒存在于目前公认的人类HFRS范围之外，并提示在世界上其他啮齿动物与人类接触频繁的地区可能正在发生类似人类HFRS的疾病。
