School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Lab of Nanomedicine and Omic-based Diagnostics, Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou 310058, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China.
Lab of Nanomedicine and Omic-based Diagnostics, Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou 310058, PR China.
J Control Release. 2024 Jul;371:530-554. doi: 10.1016/j.jconrel.2024.06.019. Epub 2024 Jun 13.
Wound management remains a great challenge for clinicians due to the complex physiological process of wound healing. Porous silicon (PSi) with controlled pore morphology, abundant surface chemistry, unique photonic properties, good biocompatibility, easy biodegradation and potential bioactivity represent an exciting class of materials for various biomedical applications. In this review, we focus on the recent progress of PSi in the design of advanced sensing and delivery systems for wound management applications. Firstly, we comprehensively introduce the common type, normal healing process, delaying factors and therapeutic drugs of wound healing. Subsequently, the typical fabrication, functionalization and key characteristics of PSi have been summarized because they provide the basis for further use as biosensing and delivery materials in wound management. Depending on these properties, the rise of PSi materials is evidenced by the examples in literature in recent years, which has emphasized the robust potential of PSi for wound monitoring, treatment and theranostics. Finally, challenges and opportunities for the future development of PSi-based sensors and delivery systems for wound management applications are proposed and summarized. We hope that this review will help readers to better understand current achievements and future prospects on PSi-based sensing and delivery systems for advanced wound management.
由于伤口愈合的复杂生理过程，伤口管理仍然是临床医生面临的巨大挑战。多孔硅（PSi）具有可控的孔形态、丰富的表面化学、独特的光子特性、良好的生物相容性、易于生物降解和潜在的生物活性，是一类用于各种生物医学应用的令人兴奋的材料。在这篇综述中，我们重点介绍了 PSi 在设计用于伤口管理应用的先进传感和输送系统方面的最新进展。首先，我们全面介绍了伤口愈合的常见类型、正常愈合过程、延迟因素和治疗药物。随后，总结了 PSi 的典型制造、功能化和关键特性，因为它们为 PSi 进一步用作伤口管理中的生物传感和输送材料提供了基础。基于这些特性，近年来文献中的实例证明了 PSi 材料的兴起，强调了 PSi 在伤口监测、治疗和治疗方面的强大潜力。最后，提出并总结了基于 PSi 的伤口管理应用传感器和输送系统未来发展的挑战和机遇。我们希望这篇综述能帮助读者更好地了解基于 PSi 的传感和输送系统在先进伤口管理方面的现有成果和未来前景。
