Department of Rehabilitation, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China.
Department of Intensive Care Medicine, Feicheng People's Hospital, Taian, Shandong, China.
Eur J Med Res. 2024 Jun 10;29(1):322. doi: 10.1186/s40001-024-01916-2.
Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders that affect individuals' social interactions, communication skills, and behavioral patterns, with significant individual differences and complex etiology. This article reviews the definition and characteristics of ASD, epidemiological profile, early research and diagnostic history, etiological studies, advances in diagnostic methods, therapeutic approaches and intervention strategies, social and educational integration, and future research directions. The highly heritable nature of ASD, the role of environmental factors, genetic-environmental interactions, and the need for individualized, integrated, and technology-driven treatment strategies are emphasized. Also discussed is the interaction of social policy with ASD research and the outlook for future research and treatment, including the promise of precision medicine and emerging biotechnology applications. The paper points out that despite the remarkable progress that has been made, there are still many challenges to the comprehensive understanding and effective treatment of ASD, and interdisciplinary and cross-cultural research and global collaboration are needed to further deepen the understanding of ASD and improve the quality of life of patients.
自闭症谱系障碍(ASD)是一组神经发育障碍,影响个体的社交互动、沟通技巧和行为模式,具有显著的个体差异和复杂的病因。本文综述了 ASD 的定义和特征、流行病学概况、早期研究和诊断历史、病因学研究、诊断方法的进展、治疗方法和干预策略、社会和教育融合以及未来的研究方向。强调了 ASD 的高度遗传性、环境因素的作用、遗传-环境相互作用以及个体化、综合和技术驱动的治疗策略的必要性。还讨论了社会政策与 ASD 研究的相互作用以及未来研究和治疗的前景,包括精准医学和新兴生物技术应用的前景。本文指出,尽管已经取得了显著的进展,但对于 ASD 的全面理解和有效治疗仍然存在许多挑战,需要开展跨学科和跨文化的研究和全球合作,以进一步深化对 ASD 的认识并提高患者的生活质量。