Li Jinzhi, Zhao Xichuan, Zhang Ruoqin, Zhou Di, Li Feng, Li Zhiyuan, Guo Honglian
Opt Express. 2024 Apr 22;32(9):16362-16370. doi: 10.1364/OE.520615.
Particle manipulation through the transfer of light or sound momentum has emerged as a powerful technique with immense potential in various fields, including cell biology, microparticle assembly, and lab-on-chip technology. Here, we present a novel method called Programmable Photoacoustic Manipulation (PPAM) of microparticles in liquid, which enables rapid and precise arrangement and controllable transport of numerous silica particles in water. Our approach leverages the modulation of pulsed laser using digital micromirror devices (DMD) to generate localized Lamb waves in a stainless steel membrane and acoustic waves in water. The particles undergo a mechanical force of about several µN due to membrane vibrations and an acoustic radiation force of about tens of nN from the surrounding water. Consequently, this approach surpasses the efficiency of optical tweezers by effectively countering the viscous drag imposed by water and can be used to move thousands of particles on the membrane. The high power of the pulsed laser and the programmability of the DMD enhance the flexibility in particle manipulation. By integrating the benefits of optical and acoustic manipulation, this technique holds great promise for advancing large-scale manipulation, cell assembly, and drug delivery.
通过光或声动量传递来操控粒子，已成为一种强大的技术，在包括细胞生物学、微粒组装和芯片实验室技术等各个领域具有巨大潜力。在此，我们展示了一种名为液体中微粒可编程光声操控（PPAM）的新方法，该方法能够在水中对众多二氧化硅粒子进行快速精确排列和可控运输。我们的方法利用数字微镜器件（DMD）对脉冲激光进行调制，以在不锈钢膜中产生局部兰姆波，并在水中产生声波。由于膜振动，粒子会受到约几微牛的机械力，同时还会受到来自周围水的约几十纳牛的声辐射力。因此，这种方法通过有效对抗水施加的粘性阻力，超越了光镊的效率，可用于在膜上移动数千个粒子。脉冲激光的高功率和DMD的可编程性增强了粒子操控的灵活性。通过整合光学和声学操控的优点，这项技术在推进大规模操控、细胞组装和药物递送方面具有巨大潜力。
