Plunkett Caitríona, Pilkington Melissa
Manchester Metropolitan University, UK.
J Health Psychol. 2025 Mar;30(3):369-383. doi: 10.1177/13591053241255053. Epub 2024 Jun 10.
Neurofibromatosis type 1 (NF1) predisposes individuals to benign and malignant tumours. Young women with NF1 (<50 years) have an up to five-fold increased risk of breast cancer. The UK adopts moderate cancer risk guidelines of NICE, advising women with NF1 to attend breast screening from 40 years. Previous results from a systematic review and meta-analysis found that breast cancer in this cohort predominantly occurs from 34 to 44 years. Without earlier screening, breast awareness is fundamental. Reflexive thematic analysis and semi-structured interview questions based on the health belief model explored whether a tailor-made breast cancer awareness intervention would be beneficial by examining beliefs, screening attitudes and breast cancer awareness of young women with NF1. Findings suggest the establishment of accessible and accurate NF1 and breast awareness information, development and implementation of a breast awareness intervention for young women with NF1, and healthcare professionals.
1型神经纤维瘤病（NF1）使个体易患良性和恶性肿瘤。患有NF1的年轻女性（<50岁）患乳腺癌的风险增加了五倍。英国采用了英国国家卫生与临床优化研究所（NICE）的中度癌症风险指南，建议患有NF1的女性从40岁开始参加乳腺癌筛查。一项系统评价和荟萃分析的先前结果发现，该队列中的乳腺癌主要发生在34至44岁之间。如果没有更早的筛查，乳房自我意识至关重要。基于健康信念模型的反思性主题分析和半结构化访谈问题，通过检查患有NF1的年轻女性的信念、筛查态度和乳腺癌意识，探讨了量身定制的乳腺癌意识干预措施是否有益。研究结果表明，应建立易于获取且准确的NF1和乳房意识信息，为患有NF1的年轻女性以及医疗保健专业人员制定并实施乳房意识干预措施。
