多潘立酮与甲氧氯普胺作为日间堕胎患者止吐药的疗效评估。
The evaluation of domperidone and metoclopramide as antiemetics in day care abortion patients.
作者信息
Waldmann C S, Verghese C, Short S M, Goldhill D R, Evans S J
出版信息
Br J Clin Pharmacol. 1985 Mar;19(3):307-10. doi: 10.1111/j.1365-2125.1985.tb02648.x.
A randomised double-blind investigation was undertaken to assess the value of domperidone and metoclopramide as prophylactic anti-emetics in unpremedicated patients undergoing general anaesthesia for therapeutic abortion on a day care basis. Sixty patients were divided into three groups, and received, at induction, one of three drugs intravenously. The incidences of postoperative nausea and vomiting were 35% in the group receiving normal saline as placebo, 30% in the group receiving 10 mg domperidone and 25% in the group receiving 10 mg metoclopramide; these were not statistically significantly different. Furthermore, there was no statistically significant difference in the incidence of postoperative nausea and vomiting as influenced by age, weight, length of gestation, anaesthetic time and a history of nausea and vomiting during the pregnancy.
进行了一项随机双盲研究，以评估多潘立酮和甲氧氯普胺作为预防性止吐药在日间接受治疗性流产全身麻醉且未用术前药患者中的价值。60例患者分为三组，诱导时静脉注射三种药物之一。接受生理盐水作为安慰剂组的术后恶心和呕吐发生率为35%，接受10mg多潘立酮组为30%，接受10mg甲氧氯普胺组为25%；这些差异无统计学意义。此外，年龄、体重、妊娠时长、麻醉时间以及孕期恶心和呕吐史对术后恶心和呕吐发生率的影响也无统计学意义。
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