Qin Chuang, Ye Xiaofei, Luo Hongliang, Jin Hu, Liu Qiang, Li Jiangfa
Hepatobiliary Surgery, Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou City, Guangxi, People's Republic of China.
Hepatobiliary Surgery, The Affiliated Hospital of Guilin Medical University, Guilin City, Guangxi, People's Republic of China.
Int J Gen Med. 2024 Jun 6;17:2655-2671. doi: 10.2147/IJGM.S460549. eCollection 2024.
This study contributes to the evolving understanding of the pivotal involvement of Sirtuins (SIRTs) in various human cancers, with a particular focus on elucidating their expression patterns and clinical relevance within the context of hepatocellular carcinoma (HCC). The investigation involves a comprehensive analysis of mRNA expression and prognostic implications associated with distinct SIRTs in HCC.
Initial data pertaining to SIRT expression in HCC patients were collated from publicly accessible databases. Subsequently, the expression levels of select members of the SIRT family were validated using clinicopathological specimens from HCC patients. Additionally, HCC tissue microarray was employed to scrutinize the correlation between SIRT7 expression and HCC prognosis.
The findings indicated a substantial upregulation of SIRT2, SIRT3, SIRT4, SIRT6, and SIRT7 in HCC tissues. Survival analysis underscored a pronounced association between elevated mRNA levels of SIRT3, SIRT6, and SIRT7 and an adverse prognosis for HCC patients. Particularly, SIRT7 emerged as a potential independent risk factor for poor prognosis in HCC patients. Examination of the HCC tissue microarray revealed heightened expression of SIRT7 in 68 cases (54.8%) of HCC tissues. Multivariate analysis established high SIRT7 expression as an independent risk factor for diminished Disease-Free Survival (DFS) and Overall Survival (OS) in HCC patients.
The aberrant expression of SIRT7 presents itself may be as a novel biomarker for predicting the prognosis of HCC patients.
本研究有助于深化对沉默调节蛋白（SIRTs）在各种人类癌症中的关键作用的理解，尤其专注于阐明其在肝细胞癌（HCC）背景下的表达模式及临床相关性。该研究涉及对HCC中不同SIRTs的mRNA表达及预后影响进行全面分析。
从可公开获取的数据库整理HCC患者中SIRT表达的初始数据。随后，使用HCC患者的临床病理标本验证SIRT家族特定成员的表达水平。此外，采用HCC组织芯片来研究SIRT7表达与HCC预后之间的相关性。
研究结果表明，HCC组织中SIRT2、SIRT3、SIRT4、SIRT6和SIRT7显著上调。生存分析强调，SIRT3、SIRT6和SIRT7的mRNA水平升高与HCC患者的不良预后之间存在明显关联。特别是，SIRT7成为HCC患者预后不良的潜在独立危险因素。对HCC组织芯片的检查显示，68例（54.8%）HCC组织中SIRT7表达升高。多变量分析确定高SIRT7表达是HCC患者无病生存期（DFS）和总生存期（OS）降低的独立危险因素。
SIRT7的异常表达可能是预测HCC患者预后的一种新型生物标志物。
