He Qikuan, Chen Kai, Ye Ruifan, Dai Ninggao, Guo Pengyi, Wang Leixi
Department of General Surgery, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China.
Department of Medicine, Wenzhou Medical University Renji College, Wenzhou, Zhenjiang 325035, P.R. China.
Oncol Lett. 2020 Apr;19(4):3278-3288. doi: 10.3892/ol.2020.11432. Epub 2020 Mar 3.
Ovarian cancer (OC) is the fifth most frequent cause of cancer-associated mortality worldwide, and is accompanied by asymptomatic progression. Sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide-dependent protein deacetylases, comprising seven members (SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT7). Accumulating evidence has demonstrated that SIRTs act as prognostic estimators in certain types of cancer such as lung cancer, prostate cancer, gastric cancer, breast cancer and colorectal cancer. However, it remains unknown whether individual SIRTs can serve as independent prognostic factors in OC. In the present study, the Kaplan-Meier plotter online database was utilized to examine the prognostic values of SIRT mRNA expression in patients with OC. The results demonstrated that the overexpression of SIRT3, SIRT5, SIRT6 and SIRT7 mRNAs was associated with a good prognosis in patients, whereas elevated mRNA levels of SIRT1 and SIRT4 indicated poor survival in patients with OC. In addition, among the favorable predictors, SIRT3, SIRT5, SIRT6 and SIRT7 overexpression were associated with overall survival (OS), according to clinical characteristics, such as histological classification, clinical stage, pathology grade, drug therapy and tumor protein p53 mutation status in patients with OC. Similarly, SIRT4 mRNA overexpression was associated with poor OS in pathological grade III cancer. High SIRT1 and SIRT4 expression were associated with unfavorable OS at all clinical stages. Furthermore, SIRT1 and SIRT4 were negatively associated with OS in drug-treated patients. In summary, the present study demonstrated that the SIRT family is associated with the prognosis of human OC, suggesting that individual SIRTs may also act as prognostic predictors in patients.
卵巢癌（OC）是全球癌症相关死亡的第五大常见原因，且伴有无症状进展。沉默调节蛋白（SIRTs）是一类烟酰胺腺嘌呤二核苷酸依赖性蛋白脱乙酰酶，由七个成员组成（SIRT1、SIRT2、SIRT3、SIRT4、SIRT5、SIRT6和SIRT7）。越来越多的证据表明，SIRTs在某些类型的癌症如肺癌、前列腺癌、胃癌、乳腺癌和结直肠癌中可作为预后评估指标。然而，个体SIRTs是否能作为OC的独立预后因素仍不清楚。在本研究中，利用Kaplan-Meier Plotter在线数据库检测SIRT mRNA表达在OC患者中的预后价值。结果表明，SIRT3、SIRT5、SIRT6和SIRT7 mRNA的过表达与患者的良好预后相关，而SIRT1和SIRT4的mRNA水平升高表明OC患者的生存期较差。此外，在有利的预测因素中，根据OC患者的组织学分类、临床分期、病理分级、药物治疗和肿瘤蛋白p53突变状态等临床特征，SIRT3、SIRT5、SIRT6和SIRT7的过表达与总生存期（OS）相关。同样，SIRT4 mRNA过表达与病理III级癌症的不良OS相关。在所有临床分期中，高SIRT1和SIRT4表达与不良OS相关。此外，在接受药物治疗的患者中，SIRT1和SIRT4与OS呈负相关。总之，本研究表明SIRT家族与人类OC的预后相关，提示个体SIRTs也可能作为患者的预后预测指标。
