Department of Pharmacology, the Blue Lab (Molecular Medicine and Toxicology) Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India.
Department of Oral Medicine and Radiology, Saveetha Dental College (SDC), Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Oral Dis. 2022 Apr;28(3):559-567. doi: 10.1111/odi.13798. Epub 2021 Mar 1.
Oral cancer is one of the most leading cancer responsible for significant morbidity and mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to regulate a variety of molecular signaling associated with different cancer types including oral malignancies. SIRT1 acts as bifunctional in a variety of cancer. In oral cancer, SIRT1 seems to work as a tumor suppressor. The carcinogenic potential of SIRT1 is also reported in oral cancer, and hence, its role is still ambiguous. SIRT2 is also said to play a dual-faced role in different types of cancers. However, in oral cancer, SIRT2 is not studied and its role remains obscure. SIRT3 expression was positively correlated with oral malignancies. However, studies also showed the anti-cancer role of SIRT3 in oral cancer. SIRT7 loss was observed in oral cancer cells, while its overexpression caused the suppression of oral cancer cells proliferation, migration, and invasiveness. The role of other SIRTs in oral cancer was studied meagerly or reports not available. To date, only the roles of SIRT1, SIRT3, and SIRT7 have been reported in oral malignancies. Therefore, understanding the regulatory mechanisms employed by sirtuins to modulate oral cancer is important for developing potential anti-cancer therapeutic strategies.
口腔癌是导致高发病率和死亡率的主要癌症之一。沉默调节蛋白（SIRTs）是 III 类组蛋白去乙酰化酶家族，已知可调节与包括口腔恶性肿瘤在内的多种癌症类型相关的多种分子信号。SIRT1 在多种癌症中充当双功能蛋白。在口腔癌中，SIRT1 似乎作为肿瘤抑制因子发挥作用。SIRT1 的致癌潜能也在口腔癌中得到报道，因此其作用仍然存在争议。SIRT2 据说在不同类型的癌症中发挥双重作用。然而，在口腔癌中，SIRT2 尚未被研究，其作用仍不清楚。SIRT3 的表达与口腔恶性肿瘤呈正相关。然而，研究还表明 SIRT3 在口腔癌中具有抗癌作用。在口腔癌细胞中观察到 SIRT7 的缺失，而其过表达导致口腔癌细胞增殖、迁移和侵袭的抑制。其他 SIRTs 在口腔癌中的作用研究较少或尚无报道。迄今为止，只有 SIRT1、SIRT3 和 SIRT7 的作用在口腔恶性肿瘤中得到了报道。因此，了解 SIRTs 调节口腔癌的调控机制对于开发潜在的抗癌治疗策略非常重要。
