Matos Ana Gabrielly de Melo, Silva Gyl Eanes Barros, Barbosa Eldevan da Silva, de Andrade Marcelo Souza, Santos Lages Joyce, Corrêa Rita da Graça Carvalhal Frazão, Oliveira Ana Gabriela Caldas, Teixeira Eliel Barbosa, da Silva Marcelli Geisse de Oliveira Prata, da Fonseca Susanne Suely Santos, Teixeira-Júnior Antonio Augusto Lima, Alves Matheus Silva, Alencar Junior Antonio Machado, Khayat André Salim, Pinho Jaqueline Diniz
Postgraduate Program in Adult Health, Federal University of Maranhão, São Luís, Brazil.
Laboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, São Luís, Brazil.
Front Genet. 2024 May 27;15:1287869. doi: 10.3389/fgene.2024.1287869. eCollection 2024.
Cervical Cancer (CC) is one of the most prevalent neoplasms among women, considered the leading cause of gynecological death worldwide, and the fourth most common type of cancer. Regional metastasis is closely related to the low effectiveness of treatment, and validating biomarkers can optimize accuracy in diagnosis and prognosis. Among the potential biomarkers associated with disease metastasis are circular RNAs (circRNAs), whose altered expression has been linked to CC progression. In this context, this systematic review aims to compile information on the clinical-pathological significance and describe the biological function of circRNAs. Inclusion and exclusion criteria were used to include relevant literature, followed by analysis. Additionally, we employed the UALCAN tools to search for host genes of circRNAs and expression data, miRTargetLink 2.0 to predict interactions of microRNA target genes and the Cytoscape software to predict possible interactions of microRNA target genes. According to the research, most circRNAs were found to be overexpressed and described as regulators of processes such as invasion, cell proliferation, apoptosis and migration. They were also implicated in clinical significance, including metastasis, TNM staging and microRNA interactions. CircRNAs may participate in critical processes in tumorigenesis; therefore, understanding the underlying molecular mechanisms of gene regulation in CC can contribute to the accuracy of diagnosis, prognosis and therapy.
宫颈癌（CC）是女性中最常见的肿瘤之一，被认为是全球妇科死亡的主要原因，也是第四大常见癌症类型。区域转移与治疗效果不佳密切相关，验证生物标志物可优化诊断和预后的准确性。与疾病转移相关的潜在生物标志物包括环状RNA（circRNA），其表达改变与CC进展有关。在此背景下，本系统综述旨在汇总有关临床病理意义的信息，并描述circRNA的生物学功能。使用纳入和排除标准纳入相关文献，随后进行分析。此外，我们使用UALCAN工具搜索circRNA的宿主基因和表达数据，使用miRTargetLink 2.0预测微小RNA靶基因的相互作用，并使用Cytoscape软件预测微小RNA靶基因的可能相互作用。根据研究，发现大多数circRNA过表达，并被描述为侵袭、细胞增殖、凋亡和迁移等过程的调节因子。它们还与临床意义有关，包括转移、TNM分期和微小RNA相互作用。CircRNA可能参与肿瘤发生的关键过程；因此，了解CC中基因调控的潜在分子机制有助于提高诊断、预后和治疗的准确性。
