Lu Zhiming, Xie Zhiheng, Shen Kaiwei, Wu Xunyuan, Feng Eryou
Fujian Medical University Union Hospital, Fuzhou, China.
Department of Orthopaedic, Anxi County Hospital, Quanzhou, China.
Front Nutr. 2024 May 27;11:1353964. doi: 10.3389/fnut.2024.1353964. eCollection 2024.
Synovial inflammation is the main reason for joint damage in patients with rheumatoid arthritis (RA). Diet is recognized as one of the therapeutic strategies to control the inflammatory activity in RA. However, few studies have investigated the association between diet and immune-inflammatory biomarkers in RA patients. Our study aims to examine the correlation between dietary inflammatory potential and systemic immune-inflammation Index (SII), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR) in the RA population.
The National Health and Nutrition Examination Survey (NHANES) was the data source utilized in this study, spanning from 1999 to 2018. The study encompassed 2,500 RA participants in total. The dietary inflammatory potential was calculated by the dietary inflammation index (DII) score based on dietary recall interviews. The generalized multiple linear regression analyses were used to evaluate the relationship between DII and immune-inflammatory markers. Furthermore, subgroup analyses and restricted cubic spline models were performed.
After full adjustments, there were significant positive correlations between DII levels and SII/NLR in RA patients (SII, β: 14.82, 95% CI: 5.14-24.50, = 0.003; NLR, β: 0.04, 95% CI: 0.01-0.08, = 0.005). It was noteworthy that inconsistent results were observed in the association between DII and SII as well as NLR in subgroups of red blood cell levels (Interaction -value <0.001).
Pro-inflammatory dietary status in the RA population is significantly positively correlated with SII and NLR, influenced by variations in red blood cell levels.
滑膜炎是类风湿关节炎（RA）患者关节损伤的主要原因。饮食被认为是控制RA炎症活动的治疗策略之一。然而，很少有研究调查饮食与RA患者免疫炎症生物标志物之间的关联。我们的研究旨在探讨RA人群中饮食炎症潜能与全身免疫炎症指数（SII）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及淋巴细胞与单核细胞比值（LMR）之间的相关性。
本研究使用的数据源为1999年至2018年的美国国家健康与营养检查调查（NHANES）。该研究共纳入2500名RA参与者。饮食炎症潜能通过基于饮食回忆访谈的饮食炎症指数（DII）评分计算得出。采用广义多元线性回归分析来评估DII与免疫炎症标志物之间的关系。此外，还进行了亚组分析和受限立方样条模型分析。
经过全面调整后，RA患者的DII水平与SII/NLR之间存在显著正相关（SII，β：14.82，95%CI：5.14 - 24.50，P = 0.003；NLR，β：0.04，95%CI：0.01 - 0.08，P = 0.005）。值得注意的是，在红细胞水平亚组中，DII与SII以及NLR之间的关联结果不一致（交互作用P值<0.001）。
RA人群中促炎饮食状态与SII和NLR显著正相关，受红细胞水平变化影响。
