Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, 6719851552, Iran.
Research Center of Oils and Fats, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Nutr J. 2022 Aug 16;21(1):53. doi: 10.1186/s12937-022-00805-w.
Diet plays an important role in regulating inflammation, which is a hallmark of rheumatoid arthritis (RA). Our aim was to investigate the association between the Dietary Inflammatory Index (DII) scores and RA activity.
This cross-sectional study was conducted on 184 patients with RA in rheumatology clinic in Kermanshah city, Iran, in 2020. RA was diagnosed according to the criteria of the 2010 American College of Rheumatology/ European League against Rheumatism. The overall inflammatory potential of the diet was extracted from a validated 168-item food frequency questioner (FFQ) using the DII. RA disease activity was assessed using Disease Activity Score 28 (DAS-28) scores. Logistic regression and one-way ANOVA/ ANCOVA were conducted.
Individuals in the highest DII quartile had the significantly higher odds of positive C-reactive protein than those in the lowest quartile of the DII scores (OR 4.5, 95% CI 1.16 - 17.41, P = 0.029). A statistically significant downward linear trend in fat-free mass and weight were observed with increasing the DII quartiles (P = 0.003, P = 0.019, respectively). Patients in the highest DII quartile had higher DAS-28 scores than those in the first quartile (Mean difference: 1.16, 95% CI 0.51 - 1.81, P < 0.001) and second quartile of the DII scores (Mean difference: 1.0, 95% CI 0.34 - 1.65, P < 0.001).
Our results indicated that reducing inflammation through diet might be one of the therapeutic strategies to control and reduce the disease activity in RA patients.
饮食在调节炎症中起着重要作用，炎症是类风湿关节炎（RA）的一个标志。我们的目的是研究饮食炎症指数（DII）评分与 RA 活动之间的关系。
本横断面研究于 2020 年在伊朗克尔曼沙阿市的风湿病诊所对 184 例 RA 患者进行。RA 根据 2010 年美国风湿病学会/欧洲抗风湿病联盟的标准进行诊断。使用 DII 从经过验证的 168 项食物频率问卷（FFQ）中提取饮食的总体炎症潜力。使用疾病活动评分 28（DAS-28）评分评估 RA 疾病活动。进行逻辑回归和单因素方差分析/协方差分析。
DII 评分最高四分位数的个体与 DII 评分最低四分位数的个体相比，C 反应蛋白阳性的可能性显著更高（OR 4.5，95%CI 1.16-17.41，P=0.029）。随着 DII 四分位数的增加，无脂肪质量和体重呈统计学显著下降线性趋势（P=0.003，P=0.019）。DII 评分最高四分位数的患者的 DAS-28 评分高于第一四分位数（平均差值：1.16，95%CI 0.51-1.81，P<0.001）和第二四分位数（平均差值：1.0，95%CI 0.34-1.65，P<0.001）。
我们的结果表明，通过饮食减少炎症可能是控制和降低 RA 患者疾病活动的治疗策略之一。
