Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi, 710127, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 614001, China.
J Mater Chem B. 2024 Jul 10;12(27):6521-6531. doi: 10.1039/d4tb00803k.
Contrast-enhanced magnetic resonance angiography (CE-MRA) plays a critical role in diagnosing and monitoring various vascular diseases. Achieving high-sensitivity detection of vascular abnormalities in CE-MRA depends on the properties of contrast agents. In contrast to clinically used gadolinium-based contrast agents (GBCAs), the new generation of ultrasmall ferrite nanoparticles-based contrast agents have high relaxivity, long blood circulation time, easy surface functionalization, and high biocompatibility, hence showing promising prospects in CE-MRA. This review aims to comprehensively summarize the advancements in ultrasmall ferrite nanoparticles-enhanced MRA for detecting vascular diseases. Additionally, this review also discusses the future clinical translational potential of ultrasmall ferrite nanoparticles-based contrast agents for vascular imaging. By investigating the current status of research and clinical applications, this review attempts to outline the progress, challenges, and future directions of using ultrasmall ferrite nanoparticles to drive the field of CE-MRA into a new frontier of accuracy and diagnostic efficacy.
对比增强磁共振血管成像（CE-MRA）在诊断和监测各种血管疾病方面发挥着关键作用。实现 CE-MRA 中血管异常的高灵敏度检测取决于对比剂的特性。与临床使用的基于钆的造影剂（GBCAs）相比，新一代基于超小铁氧体纳米颗粒的造影剂具有高弛豫率、长血液循环时间、易于表面功能化和高生物相容性，因此在 CE-MRA 中具有广阔的应用前景。本综述旨在全面总结超小铁氧体纳米颗粒增强 MRA 在检测血管疾病方面的最新进展。此外，本综述还讨论了基于超小铁氧体纳米颗粒的造影剂在血管成像方面的未来临床转化潜力。通过研究研究现状和临床应用，本综述试图概述使用超小铁氧体纳米颗粒推动 CE-MRA 领域进入准确性和诊断效果新前沿的进展、挑战和未来方向。
