文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

聚乙二醇（PEG）包覆的超小粒径、高弛豫率锰掺杂氧化铁纳米粒子的合成及其在 T/T 双模态磁共振成像中的应用。

Synthesis Of PEG-Coated, Ultrasmall, Manganese-Doped Iron Oxide Nanoparticles With High Relaxivity For T/T Dual-Contrast Magnetic Resonance Imaging.

机构信息

Department of Radiology, Xinqiao Hospital, Army Medical University, Chongqing, People's Republic of China.

出版信息

Int J Nanomedicine. 2019 Oct 24;14:8499-8507. doi: 10.2147/IJN.S219749. eCollection 2019.

DOI:10.2147/IJN.S219749
PMID:31695377
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6817351/
Abstract

BACKGROUND: Beyond magnetic resonance imaging (MRI), which has been widely used clinically, molecular MRI (mMRI) can further provide qualitative and quantitative information at the cellular and molecular levels. However, the diagnostic accuracy may not be satisfactory via single-contrast mMRI due to some interferences in vivo. T/T dual-contrast MRI using the same contrast agent (CA) could significantly improve the detection accuracy. Therefore, in this study, we fabricated poly(ethylene glycol) (PEG)-coated, manganese-doped iron oxide nanocomposites (Mn-IONPs@PEG) as T/T dual-contrast CA, and evaluated its feasibility of T/T dual-contrast MRI in vitro and in vivo. METHODS: Mn-IONPs were prepared by the thermal decomposition of iron-eruciate and manganese-oleate complexes and were coated with 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy[polyethylene glycol]-2000) (DSPE-PEG 2000). The physicochemical properties and cytotoxicity of the Mn-IONPs were fully characterized, followed by MRI in vitro and in vivo. RESULTS: Ultrasmall 3 nm-sized nanoparticles were successfully prepared and were identified using transmission electron microscopy (TEM), high-resolution TEM, and X-ray diffraction. After coating with DSPE-PEG, the Mn-IONPs@PEG displayed excellent hydrophilicity and good biocompatibility. Due to the manganese-doping and PEG coating, the Mn-IONPs@PEG showed good relaxivity in vitro. Especially, the Mn-IONPs@PEG coated with DSPE-PEG following a mass ratio to Mn-IONPs of 1:20 showed harmonious longitudinal relaxivity ( = 7.1 mMs) and transversal relaxivity ( = 120.9 mMs), making it a better candidate for T/T dual-contrast mMRI. After administrated via a caudal vein, the Mn-IONPs@PEG can induce significant enhancement in both T-weighted and T-weighted MR images and the time at 10 mins after injection was regarded as a suitable time for imaging because both the T and T enhancement were optimum at that time. CONCLUSION: The obtained Mn-IONPs@PEG exhibited good and and was a reasonable candidate for T/T dual-contrast mMRI.

摘要

背景：除了广泛应用于临床的磁共振成像（MRI）外，分子 MRI（mMRI）还可以在细胞和分子水平上提供定性和定量信息。然而，由于体内的一些干扰，单一对比 mMRI 的诊断准确性可能并不理想。使用相同造影剂（CA）的 T/T 双对比 MRI 可以显著提高检测准确性。因此，在这项研究中，我们制备了聚乙二醇（PEG）包覆的锰掺杂氧化铁纳米复合材料（Mn-IONPs@PEG）作为 T/T 双对比 CA，并评估了其在体外和体内 T/T 双对比 MRI 的可行性。 方法：Mn-IONPs 通过铁草酸盐和油酸锰配合物的热分解制备，并通过 1,2-二硬脂酰基-sn-甘油-3-磷酸乙醇胺-N-（甲氧基[聚乙二醇]-2000）（DSPE-PEG 2000）进行包覆。对 Mn-IONPs 的理化性质和细胞毒性进行了充分的表征，随后进行了体外和体内 MRI 研究。 结果：通过透射电子显微镜（TEM）、高分辨率 TEM 和 X 射线衍射成功制备了超小 3nm 尺寸的纳米粒子。经 DSPE-PEG 包覆后，Mn-IONPs@PEG 表现出优异的亲水性和良好的生物相容性。由于锰掺杂和 PEG 包覆，Mn-IONPs@PEG 在体外具有良好的弛豫率。特别是，DSPE-PEG 与 Mn-IONPs 的质量比为 1:20 时，Mn-IONPs@PEG 表现出良好的纵向弛豫率（ = 7.1 mMs）和横向弛豫率（ = 120.9 mMs），使其成为 T/T 双对比 mMRI 的较好候选物。尾静脉给药后，Mn-IONPs@PEG 可引起 T 加权和 T 加权 MR 图像的显著增强，注射后 10 分钟是成像的合适时间，因为此时 T 和 T 增强均达到最佳。 结论：所获得的 Mn-IONPs@PEG 表现出良好的弛豫性能，是 T/T 双对比 mMRI 的合理候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeaa/6817351/4169b0631cbb/IJN-14-8499-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeaa/6817351/5da9875c2518/IJN-14-8499-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeaa/6817351/55c78aa1b667/IJN-14-8499-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeaa/6817351/e231b5541146/IJN-14-8499-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeaa/6817351/4169b0631cbb/IJN-14-8499-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeaa/6817351/5da9875c2518/IJN-14-8499-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeaa/6817351/55c78aa1b667/IJN-14-8499-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeaa/6817351/e231b5541146/IJN-14-8499-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aeaa/6817351/4169b0631cbb/IJN-14-8499-g0004.jpg

相似文献

[1]
Synthesis Of PEG-Coated, Ultrasmall, Manganese-Doped Iron Oxide Nanoparticles With High Relaxivity For T/T Dual-Contrast Magnetic Resonance Imaging.

Int J Nanomedicine. 2019-10-24

[2]
Fabrication and evaluation of tumor-targeted positive MRI contrast agent based on ultrasmall MnO nanoparticles.

Colloids Surf B Biointerfaces. 2015-4-29

[3]
Ultrasmall Ferrite Nanoparticles Synthesized via Dynamic Simultaneous Thermal Decomposition for High-Performance and Multifunctional T Magnetic Resonance Imaging Contrast Agent.

ACS Nano. 2017-4-6

[4]
One-pot preparation of hydrophilic manganese oxide nanoparticles as T nano-contrast agent for molecular magnetic resonance imaging of renal carcinoma in vitro and in vivo.

Biosens Bioelectron. 2017-10-27

[5]
Targeting T1 and T2 dual modality enhanced magnetic resonance imaging of tumor vascular endothelial cells based on peptides-conjugated manganese ferrite nanomicelles.

Int J Nanomedicine. 2016-8-19

[6]
One-pot facile synthesis of PEGylated superparamagnetic iron oxide nanoparticles for MRI contrast enhancement.

Mater Sci Eng C Mater Biol Appl. 2014-4-28

[7]
Composition-Tunable Ultrasmall Manganese Ferrite Nanoparticles: Insights into their T Contrast Efficacy.

Theranostics. 2019-2-28

[8]
The effect of metal ions on endogenous melanin nanoparticles used as magnetic resonance imaging contrast agents.

Biomater Sci. 2019-11-15

[9]
Large-scale synthesis of uniform and extremely small-sized iron oxide nanoparticles for high-resolution T1 magnetic resonance imaging contrast agents.

J Am Chem Soc. 2011-7-25

[10]
Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic resonance contrast agents.

Biomaterials. 2015-3-17

引用本文的文献

[1]
Iron oxide based magnetic nanoparticles for hyperthermia, MRI and drug delivery applications: a review.

RSC Adv. 2025-4-14

[2]
Customized Sized Manganese Sulfide Nanospheres as Efficient T MRI Contrast Agents for Enhanced Tumor Theranostics.

Biomater Res. 2024-12-11

[3]
Optical and MRI Multimodal Tracing of Stem Cells In Vivo.

Mol Imaging. 2023

[4]
Mn-Doped Nano-Hydroxyapatites as Theranostic Agents with Tumor pH-Amplified MRI-Signal Capabilities for Guiding Photothermal Therapy.

Int J Nanomedicine. 2023

[5]
Effect of manganese substitution of ferrite nanoparticles on particle grain structure.

Nanoscale Adv. 2022-8-25

[6]
Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition.

J Nanobiotechnology. 2022-7-14

[7]
Contrast Agents for Hepatocellular Carcinoma Imaging: Value and Progression.

Front Oncol. 2022-6-2

[8]
Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imaging.

Bioact Mater. 2021-10-19

[9]
Imaging Constructs: The Rise of Iron Oxide Nanoparticles.

Molecules. 2021-6-5

[10]
Construction of nanomaterials as contrast agents or probes for glioma imaging.

J Nanobiotechnology. 2021-5-3

本文引用的文献

[1]
Bio-inspired synthesis of PEGylated polypyrrole@polydopamine nanocomposites as theranostic agents for T-weighted MR imaging guided photothermal therapy.

J Mater Chem B. 2017-2-7

[2]
T-T molecular magnetic resonance imaging of renal carcinoma cells based on nano-contrast agents.

Int J Nanomedicine. 2018-8-10

[3]
Polymeric Nanoparticles with a Glutathione-Sensitive Heterodimeric Multifunctional Prodrug for In Vivo Drug Monitoring and Synergistic Cancer Therapy.

Angew Chem Int Ed Engl. 2018-5-14

[4]
Engineered contrast agents in a single structure for T-T dual magnetic resonance imaging.

Nanoscale. 2018-4-5

[5]
Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents.

Chem Soc Rev. 2017-11-27

[6]
One-Step Fast Synthesis of Nanoparticles for MRI: Coating Chemistry as the Key Variable Determining Positive or Negative Contrast.

Langmuir. 2017-9-18

[7]
A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy.

ACS Nano. 2017-7-7

[8]
Ultrasmall Ferrite Nanoparticles Synthesized via Dynamic Simultaneous Thermal Decomposition for High-Performance and Multifunctional T Magnetic Resonance Imaging Contrast Agent.

ACS Nano. 2017-4-6

[9]
Nanomaterials for In Vivo Imaging.

Chem Rev. 2017-1-3

[10]
Compact Micellization: A Strategy for Ultrahigh T1 Magnetic Resonance Contrast with Gadolinium-Based Nanocrystals.

ACS Nano. 2016-9-8

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索