From the Department of Preventive and Public Health Dentistry, Chonnam National University School of Dentistry, Gwangju, Republic of Korea.
Menopause. 2024 Aug 1;31(8):663-668. doi: 10.1097/GME.0000000000002375. Epub 2024 Jun 11.
Menopause is characterized by changes in reproductive hormone levels that can negatively affect bone. Chronic kidney disease (CKD) and tooth loss are also important and common health issues after menopause. This study aimed to evaluate the association between CKD and tooth loss in postmenopausal women.
The study evaluated 64,971 participants who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) from 2010-2018, including postmenopausal women, aged 40 to 79 years. Participants were divided into two groups based on the number of teeth in their dentition (≥20 and <20).
The association between CKD and tooth loss was analyzed using multivariate logistic regression. Age, income, education, smoking, alcohol intake, body mass index, hypertension, diabetes, annual oral examination, toothbrushing, and the use of oral care products were considered. Subgroup analyses were further conducted according to age (40-65 yr and 66-79 yr).
After adjusting for covariates, CKD and estimated glomerular filtration rate were significantly associated with having ≥20 teeth (PT20; CKD: odds ratio [OR] 1.41, 95% confidence interval [CI] 1.04-1.90; estimated glomerular filtration rate (10 mL/min/1.73 m 2 ): OR 0.90, 95% CI 0.86-0.94). Importantly, the association between CKD and PT20 was significant in postmenopausal women, aged 66 to 79 years (OR 1.45, 95% CI 1.05-2.01).
In postmenopausal women, CKD and tooth loss may be associated. The association is significant in postmenopausal women, aged 66 to 79 years.
绝经后生殖激素水平的变化会对骨骼产生负面影响。慢性肾脏病（CKD）和牙齿缺失也是绝经后重要且常见的健康问题。本研究旨在评估绝经后妇女 CKD 与牙齿缺失之间的关系。
本研究评估了 2010-2018 年参加韩国国家健康和营养调查（KNHANES）的 64971 名参与者，包括绝经后 40-79 岁的女性。参与者根据牙齿数（≥20 颗和＜20 颗）分为两组。
使用多变量逻辑回归分析 CKD 与牙齿缺失之间的关系。年龄、收入、教育、吸烟、饮酒、体重指数、高血压、糖尿病、年度口腔检查、刷牙和使用口腔护理产品均被考虑在内。进一步根据年龄（40-65 岁和 66-79 岁）进行亚组分析。
在调整了协变量后，CKD 和估算肾小球滤过率与拥有≥20 颗牙齿（PT20）显著相关（CKD：比值比[OR]1.41，95%置信区间[CI]1.04-1.90；估算肾小球滤过率（10mL/min/1.73m2）：OR0.90，95%CI0.86-0.94）。重要的是，CKD 与 PT20 在年龄 66-79 岁的绝经后妇女中具有显著相关性（OR1.45，95%CI1.05-2.01）。
在绝经后妇女中，CKD 和牙齿缺失可能相关。这种相关性在年龄 66-79 岁的绝经后妇女中更为显著。
