Clinical Pharmacology and Toxicology, General Internal Medicine, University Hospital of Bern, Anna-Von-Krauchthal-Weg 7, 3010, Bern, Switzerland.
Graduate School for Health Sciences, University of Bern, Bern, Switzerland.
Int J Clin Pharm. 2024 Oct;46(5):1010-1023. doi: 10.1007/s11096-024-01741-x. Epub 2024 Jun 11.
Chronic non-cancer pain may affect up to 51% of the general population. Pharmacist interventions have shown promise in enhancing patient safety and outcomes. However, our understanding of the scope of pharmacists' interventions remains incomplete.
Our goal was to characterise pharmacists' interventions for the management of chronic non-cancer pain.
Medline, Embase, PsycINFO via Ovid, CINAHL via EBSCO databases and the Cochrane Library were systematically searched. Abstracts and full texts were independently screened by two reviewers. Data were extracted by one reviewer, and validated by the second. Outcomes of studies were charted using the dimensions of the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT).
Forty-eight reports were included. Interventions ensuring appropriate drug prescription occurred in 37 (79%) studies. Patient education and healthcare professional education were reported in 28 (60%) and 5 (11%) studies, respectively. Therapy monitoring occurred in 17 (36%) studies. Interventions regularly involved interprofessional collaboration. A median of 75% of reported outcome domains improved due to pharmacist interventions, especially patient disposition (adherence), medication safety and satisfaction with therapy.
Pharmacists' interventions enhanced the management of chronic non-cancer pain. Underreported outcome domains and interventions, such as medication management, merit further investigation.
慢性非癌性疼痛可能影响高达 51%的普通人群。药师干预已被证明可以提高患者的安全性和治疗效果。然而,我们对药师干预范围的理解仍不完整。
我们的目标是描述药师干预慢性非癌性疼痛管理的情况。
通过 Ovid 检索 Medline、Embase、PsycINFO、EBSCO 的 CINAHL 数据库以及 Cochrane 图书馆,对文献进行系统检索。由两名评审员独立筛选摘要和全文。由一名评审员提取数据,另一名评审员进行验证。使用临床试验中方法、测量和疼痛评估倡议(IMMPACT)的维度来绘制研究结果图表。
共纳入 48 份报告。有 37 项(79%)研究报道了确保药物处方适当的干预措施。有 28 项(60%)和 5 项(11%)研究分别报道了患者教育和医疗保健专业人员教育。有 17 项(36%)研究进行了治疗监测。干预措施通常涉及多专业合作。由于药师干预,报告的 75%的结果维度得到改善,尤其是患者处置(依从性)、药物安全性和对治疗的满意度。
药师干预可增强慢性非癌性疼痛的管理。值得进一步研究报告中未涉及的干预措施和结果领域,如药物管理。