From the Department of Nuclear Medicine, The Children's Hospital at Westmead, Sydney Children's Hospitals Network, Sydney, Australia.
Cancer Centre for Children, The Children's Hospital at Westmead, Westmead, Australia.
Clin Nucl Med. 2024 Oct 1;49(10):e506-e508. doi: 10.1097/RLU.0000000000005302. Epub 2024 May 31.
An 11-year-old girl presented with focal impaired awareness seizures. MRI brain demonstrated a T2 hyperintense cortical lesion in the left temporal lobe with surrounding vasogenic edema. 18 F-FDG PET/CT was arranged to assess metabolic activity of the cerebral lesion, to screen the whole body for other metabolically active lesions, and to assist biopsy planning. The study demonstrated intensely increased FDG uptake within the left temporal lobe lesion without evidence of hypermetabolic lesions elsewhere on the whole-body acquisition. The brain lesion was excised, and histopathology and molecular testing were consistent with ALK-positive histiocytosis.
一名 11 岁女孩出现局灶性意识障碍性癫痫发作。脑部 MRI 显示左颞叶 T2 高信号皮质病变，伴有周围血管源性水肿。安排 18F-FDG PET/CT 检查以评估脑部病变的代谢活性，对全身进行其他代谢活性病变筛查，并协助活检计划。研究显示，左颞叶病变内 FDG 摄取明显增加，全身采集未见其他高代谢病变的证据。切除脑部病变，组织病理学和分子检测与 ALK 阳性组织细胞增多症一致。
