输入荷兰的耐氯喹恶性疟
Chloroquine-resistant falciparum malaria imported into the Netherlands.
作者信息
Wetsteyn J C, de Geus A
出版信息
Bull World Health Organ. 1985;63(1):101-8.
Abstract
A prospective study of imported chloroquine-resistant falciparum malaria in the Netherlands is described. From 1979 to 1983, 77 non-immune patients were investigated; in 41 (53%) decreased sensitivity of Plasmodium falciparum to chloroquine could be confirmed. Signs and symptoms in these patients differ from the classical picture. Resistance to sulfadoxine-pyrimethamine (Fansidar) was established in 6 patients. Parasitaemia was found twice during dapsone-pyrimethamine (Maloprim) prophylaxis. The implications for advice on treatment and prophylaxis are discussed.
摘要
本文描述了在荷兰进行的一项关于输入性氯喹耐药恶性疟的前瞻性研究。1979年至1983年期间，对77名非免疫患者进行了调查；其中41名（53%）患者体内的恶性疟原虫对氯喹的敏感性降低得到了证实。这些患者的体征和症状与典型表现有所不同。6名患者被确定对磺胺多辛-乙胺嘧啶（Fansidar）耐药。在服用氨苯砜-乙胺嘧啶（Maloprim）预防期间，有两次发现了疟原虫血症。文中还讨论了对治疗和预防建议的影响。
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