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Survey of use of malaria prevention measures by Canadians visiting India.访问印度的加拿大人疟疾预防措施使用情况调查。
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The pharmacokinetics of three multiple dose regimens of chloroquine: implications for malaria chemoprophylaxis.氯喹三种多剂量给药方案的药代动力学：对疟疾化学预防的意义。
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本文引用的文献

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HPLC-analysis and preliminary pharmacokinetic parameter estimations of chloroquine.
Pharm Weekbl Sci. 1981 Dec 18;3(6):263-7.
2
Fansidar-induced Stevens-Johnson Syndrome.Fansidar诱发的史蒂文斯-约翰逊综合征。
N Engl J Med. 1982 Dec 9;307(24):1529-30. doi: 10.1056/NEJM198212093072425.
3
Chloroquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture.
Trop Geogr Med. 1981 Mar;33(1):50-4.
4
Plasmodium falciparum in vitro: determination of chloroquine sensitivity of three new strains by a modified 48-hour test.恶性疟原虫体外培养：采用改良的48小时试验测定三株新菌株对氯喹的敏感性
Am J Trop Med Hyg. 1980 May;29(3):339-42. doi: 10.4269/ajtmh.1980.29.339.
5
Chemoprophylaxis of malaria in Africa: the spent "magic bullet".非洲疟疾的化学预防：失效的“神奇子弹”
Br Med J (Clin Res Ed). 1982 Sep 11;285(6343):674-6. doi: 10.1136/bmj.285.6343.674.
6
Fansidar-resistant Plasmodium falciparum infection from Tanzania.来自坦桑尼亚的对 Fansidar 耐药的恶性疟原虫感染
Trop Geogr Med. 1982;34(3):263-5.
7
A case of fansidar-resistant Plasmodium falciparum from Tanzania.坦桑尼亚出现的一例对 Fansidar 耐药的恶性疟原虫病例。
Trop Geogr Med. 1982;34(3):261-3.
8
Serious reactions during malaria prophylaxis with pyrimethamine-sulfadoxine.使用乙胺嘧啶-磺胺多辛进行疟疾预防期间的严重反应。
Lancet. 1982 Oct 30;2(8305):994. doi: 10.1016/s0140-6736(82)90202-1.
9
Pyrimethamine/sulfadoxine resistant falciparum malaria acquired at Dar es Salaam, Tanzania.
Lancet. 1982 May 15;1(8281):1118-9. doi: 10.1016/s0140-6736(82)92294-2.
10
Drug therapy for Plasmodium falciparum malaria resistant to pyrimethamine-sulfadoxine (Fansidar). A study of alternate regimens in Eastern Thailand, 1980.对乙胺嘧啶-磺胺多辛（Fansidar）耐药的恶性疟原虫疟疾的药物治疗。1980年泰国东部替代治疗方案的研究。
Lancet. 1981 Nov 14;2(8255):1066-9. doi: 10.1016/s0140-6736(81)91274-5.

输入荷兰的耐氯喹恶性疟

Chloroquine-resistant falciparum malaria imported into the Netherlands.

作者信息

Wetsteyn J C, de Geus A

出版信息

Bull World Health Organ. 1985;63(1):101-8.

PMID:3886183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2536346/
Abstract

A prospective study of imported chloroquine-resistant falciparum malaria in the Netherlands is described. From 1979 to 1983, 77 non-immune patients were investigated; in 41 (53%) decreased sensitivity of Plasmodium falciparum to chloroquine could be confirmed. Signs and symptoms in these patients differ from the classical picture. Resistance to sulfadoxine-pyrimethamine (Fansidar) was established in 6 patients. Parasitaemia was found twice during dapsone-pyrimethamine (Maloprim) prophylaxis. The implications for advice on treatment and prophylaxis are discussed.

摘要

本文描述了在荷兰进行的一项关于输入性氯喹耐药恶性疟的前瞻性研究。1979年至1983年期间，对77名非免疫患者进行了调查；其中41名（53%）患者体内的恶性疟原虫对氯喹的敏感性降低得到了证实。这些患者的体征和症状与典型表现有所不同。6名患者被确定对磺胺多辛-乙胺嘧啶（Fansidar）耐药。在服用氨苯砜-乙胺嘧啶（Maloprim）预防期间，有两次发现了疟原虫血症。文中还讨论了对治疗和预防建议的影响。