Reacher M, Campbell C C, Freeman J, Doberstyn E B, Brandling-Bennett A D
Lancet. 1981 Nov 14;2(8255):1066-9. doi: 10.1016/s0140-6736(81)91274-5.
A trial of drug regimens for treating Plasmodium falciparum malaria was conducted in a refugee camp in eastern Thailand where extensive 'Fansidar' (pyrimethamine-sulfadoxine) resistance had been demonstrated. The efficacy of quinine alone was compared to that of quinine combined with either fansidar or tetracycline. Quinine alone cleared the parasitaemia in 57 of 59 patients but failed to cure approximately one-third of these patients after 7 or 10 days of therapy. The addition of fansidar to quinine therapy did not significantly improve the overall cure rate. Tetracycline given for 10 days in combination with quinine cured all patients, suggesting that tetracycline should be considered in treating patients with falciparum malaria contracted in the area of the Thai-Kampuchean border.
在泰国东部一个已证实存在广泛“Fansidar”（乙胺嘧啶-磺胺多辛）耐药性的难民营中，开展了一项治疗恶性疟原虫疟疾的药物方案试验。将单独使用奎宁的疗效与奎宁联合Fansidar或四环素的疗效进行了比较。单独使用奎宁使59例患者中的57例疟原虫血症清除，但在治疗7天或10天后，约三分之一的这些患者未被治愈。在奎宁治疗中添加Fansidar并未显著提高总体治愈率。与奎宁联合使用10天的四环素治愈了所有患者，这表明在治疗在泰国-柬埔寨边境地区感染恶性疟的患者时应考虑使用四环素。
