自发性糖尿病：用抗大鼠淋巴细胞抗血清使BB/W大鼠的糖尿病逆转及预防
Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes.
作者信息
Like A A, Rossini A A, Guberski D L, Appel M C, Williams R M
出版信息
Science. 1979 Dec 21;206(4425):1421-3. doi: 10.1126/science.388619.
PMID:388619
Abstract
Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morpholigic and physiologic characteristics of human insulin-dependent diabetes mellitus.
摘要
给大鼠淋巴细胞注射兔抗血清，可使36%的自发性糖尿病大鼠（生物繁殖/伍斯特品系）的高血糖症得到缓解，并预防易患糖尿病的非糖尿病对照大鼠发病。这些发现强化了一种假说，即细胞介导的自身免疫在这种模拟人类胰岛素依赖型糖尿病许多形态学和生理学特征的动物模型的糖尿病发病机制中起作用。
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