MySpace Lab, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Service of Neuropsychology and Neurorehabilitation, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
BMC Neurol. 2024 Jun 11;24(1):196. doi: 10.1186/s12883-024-03648-6.
Following a stroke, patients may suffer from alterations in the perception of their own body due to an acquired deficit in body representations. While such changes may impact their quality of life as well as recovery, they are not systematically assessed in clinical practice. This study aims at providing a better understanding of the rate, evolution, and impact on recovery of upper limb (UL) body perceptions (BPs) alterations following stroke. In addition, we will investigate associations among BPs alterations items, their associations with the sensorimotor functions, UL activity, damages in brain structure and connectivity.
We developed a new tool named ALPQ (for Affected Limb Perception Questionnaire) to address the present study objectives. It assesses subjective alterations in the perception of the affected UL following stroke, by measuring several dimensions, namely: anosognosia for hemiplegia, anosodiaphoria for hemiplegia, hemiasomatognosia, somatoparaphrenia, personification of the affected limb, illusion of modification of physical characteristics (temperature, weight, length), illusory movements, super- or undernumerary limb, UL disconnection, misoplegia, and involuntary movement. This study combines a cross-sectional and longitudinal design. The completed data sample will include a minimum of 60 acute and 100 sub-acute stroke patients. When possible, patients are followed up to the chronic stage. Complementary evaluations are administered to assess patients' sensorimotor and cognitive functions as well as UL activity, and brain lesions will be analysed.
This study will provide a better understanding of BPs alterations following stroke: their rate and evolution, as well as their associations with sensorimotor deficit, cognitive profile and UL activity, brain lesions and recovery. Ultimately, the results could support the personalization of rehabilitation strategy according to patients' UL perception to maximize their recovery.
The protocol for this study has been pre-registered on the Open Science Framework on July the 7th, 2021: https://osf.io/p6v7f .
中风后，患者可能会因身体表象的获得性缺陷而出现自身身体感知的改变。尽管这些变化可能会影响他们的生活质量和康复情况，但在临床实践中并未对其进行系统评估。本研究旨在更好地了解中风后上肢（UL）身体感知（BP）改变的速度、演变及其对康复的影响。此外，我们还将调查 BP 改变项目之间的关联，以及它们与感觉运动功能、UL 活动、大脑结构和连通性损伤之间的关联。
我们开发了一种新的工具，名为 ALPQ（受影响肢体感知问卷），用于解决本研究的目标。它通过测量几个维度来评估中风后受影响 UL 感知的主观改变，这些维度包括：偏瘫性否认、偏瘫性否认、半身感觉障碍、躯体妄想症、受影响肢体的人格化、身体特征（温度、重量、长度）改变的错觉、虚幻运动、超数或少数肢体、UL 分离、误用和不自主运动。本研究结合了横断面和纵向设计。完成的数据样本将包括至少 60 名急性和 100 名亚急性中风患者。在可能的情况下，患者将被随访至慢性期。进行补充评估以评估患者的感觉运动和认知功能以及 UL 活动，并分析大脑损伤。
本研究将更好地了解中风后 BP 的改变：其速度和演变，以及与感觉运动缺陷、认知特征和 UL 活动、大脑损伤和康复的关联。最终，结果可以支持根据患者的 UL 感知来个性化康复策略，以最大限度地提高他们的康复效果。
本研究的方案已于 2021 年 7 月 7 日在开放科学框架上预先注册：https://osf.io/p6v7f。
