Grace E M, Bellamy N, Kassam Y, Buchanan W W
Curr Med Res Opin. 1985;9(6):426-9. doi: 10.1185/03007998509109614.
Thirty-six patients with definite or classical rheumatoid arthritis participated in a double-blind, randomized, placebo-controlled trial to assess the effectiveness of adding amitriptyline to the treatment regimen for the relief of pain not adequately controlled by non-steroidal anti-inflammatory drugs. Dosage of amitriptyline was increased gradually up to 25 mg 3-times daily and patients were followed up for 12 weeks. Assessments were made of joint pain and tenderness every 4 weeks. The results showed no difference between the amitriptyline and placebo-treated patients for either parameter.
三十六名确诊为典型类风湿性关节炎的患者参与了一项双盲、随机、安慰剂对照试验，以评估在治疗方案中添加阿米替林对缓解非甾体抗炎药未能充分控制的疼痛的有效性。阿米替林剂量逐渐增加至每日三次，每次25毫克，并对患者进行了12周的随访。每4周对关节疼痛和压痛进行评估。结果显示，在这两个参数上，阿米替林治疗组和安慰剂治疗组的患者之间没有差异。
