Macfarlane J G, Jalali S, Grace E M
Curr Med Res Opin. 1986;10(2):89-93. doi: 10.1185/03007998609110424.
The effect of low-dose trimipramine (25 to 75 mg/day) on joint pain and tenderness in 36 patients with rheumatoid arthritis was studied in a randomized double-blind trial carried out over a period of 12 weeks. The patients were pre-selected to include only patients who were depressed on a 'self-rating depression scale' but had no evidence of fibrositic 'trigger-points'. The results showed that joint pain and tenderness were significantly reduced with trimipramine, but depression scores remained unchanged.
在一项为期12周的随机双盲试验中，研究了低剂量曲米帕明（25至75毫克/天）对36例类风湿性关节炎患者关节疼痛和压痛的影响。预先选择的患者仅包括那些在“自评抑郁量表”上显示抑郁但没有纤维性“触发点”证据的患者。结果显示，曲米帕明可显著减轻关节疼痛和压痛，但抑郁评分保持不变。
