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一项多中心研究,调查了被送至英国10家转诊医院的马匹受污染和感染的滑膜结构进行滑膜灌洗后的长期存活率。

Multicenter study investigating long-term survival after synovial lavage of contaminated and septic synovial structures in horses presented to 10 UK referral hospitals.

作者信息

de Souza Therese C, Burford John, Busschers Evita, Freeman Sarah, Suthers Joanna M

机构信息

University of Nottingham, Nottingham, UK.

B&W Equine Hospital, Gloucestershire, UK.

出版信息

Vet Surg. 2024 Aug;53(6):1083-1092. doi: 10.1111/vsu.14107. Epub 2024 Jun 11.

Abstract

OBJECTIVE

To report the long-term survival of adult horses that were subjected to synovial lavage for treatment of contaminated and septic synovial structures.

STUDY DESIGN

Multicenter, prospective observational trial.

ANIMALS

Horses (n = 240) presented for synovial sepsis at 10 UK referral centers.

METHODS

Data for horses presented for treatment of synovial sepsis were collected over a 15 month recruitment period. Owners were contacted a minimum of 365 days after surgery using a structured client interview to assess long term survival. Descriptive statistics, and univariable and Cox proportional hazards models for postoperative survival time were developed.

RESULTS

Survival to discharge was 228/240 (95%) and overall long-term survival was 89.4% (185/207). Unknown cause of injury (p = .017), increasing duration of surgery (p = .003), increasing weight (p = .008), forelimb injuries (p = .027), and type of synovial structure (p = .008) were found to be associated with death using Cox proportional hazards models.

CONCLUSION

This study provides information on risk factors associated with survival and death after treatment for synovial sepsis at referral hospitals in the UK. Survival to discharge and long-term survival was excellent. Heavier horses, injuries affecting the forelimbs, tendon sheaths and bursae were associated with poorer long term outcomes. Longer duration of surgery was also found to be associated with a worse prognosis.

CLINICAL SIGNIFICANCE

These findings help to provide prognostic information for owners and veterinarians treating horses with synovial sepsis.

摘要

目的

报告接受滑膜灌洗治疗污染性和感染性滑膜结构的成年马的长期存活率。

研究设计

多中心前瞻性观察性试验。

动物

在英国10个转诊中心因滑膜脓毒症就诊的马(n = 240)。

方法

在15个月的招募期内收集因滑膜脓毒症接受治疗的马的数据。术后至少365天通过结构化的客户访谈联系马主,以评估长期存活率。建立了描述性统计以及术后存活时间的单变量和Cox比例风险模型。

结果

出院存活率为228/240(95%),总体长期存活率为89.4%(185/207)。使用Cox比例风险模型发现,损伤原因不明(p = 0.017)、手术时间延长(p = 0.003)、体重增加(p = 0.008)、前肢损伤(p = 0.027)和滑膜结构类型(p = 0.008)与死亡相关。

结论

本研究提供了英国转诊医院治疗滑膜脓毒症后与生存和死亡相关的风险因素信息。出院存活率和长期存活率都很高。体重较重的马、影响前肢、腱鞘和滑囊的损伤与较差的长期预后相关。手术时间延长也与较差的预后相关。

临床意义

这些发现有助于为治疗滑膜脓毒症马的马主和兽医提供预后信息。

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