Aberg H, Lindsjö M, Mörlin B
Drugs. 1985;29 Suppl 2:117-23. doi: 10.2165/00003495-198500292-00021.
The aim of this study was to compare the new vasodilator felodipine with nifedipine in 18 patients with poorly controlled hypertension. The design was a double-blind, cross-over study using a double-dummy technique. Felodipine 5mg was given 3 times daily and nifedipine 10mg 3 times daily. In case of an unsatisfactory blood pressure reduction, the drug dose was doubled. 14 patients had the higher dose of felodipine and 16 the higher dose of nifedipine. Both agents had good antihypertensive effect. After 1 week's therapy, felodipine reduced the blood pressure by 18/12 mm Hg (supine) and 18/13 mm Hg (upright), and nifedipine by 19/11 and 24/14 mm Hg, respectively. After 4 weeks' therapy, 12 hours after drug intake, felodipine reduced the blood pressure by 11/8 mm Hg (supine) and 16/8mm Hg (upright), and nifedipine by 3/2 and 6/4 mm Hg, respectively. Two patients on nifedipine withdrew from the study due to adverse reactions. In general, however, there were few side effects, with no significant difference between the drugs.
本研究旨在比较新型血管扩张剂非洛地平与硝苯地平对18例血压控制不佳的高血压患者的疗效。研究设计为采用双盲双模拟技术的交叉试验。非洛地平5毫克，每日3次；硝苯地平10毫克，每日3次。若血压降低效果不理想，则将药物剂量加倍。14例患者服用较高剂量的非洛地平，16例患者服用较高剂量的硝苯地平。两种药物均有良好的降压效果。治疗1周后，非洛地平使仰卧位血压降低18/12毫米汞柱，直立位血压降低18/13毫米汞柱；硝苯地平使仰卧位血压降低19/11毫米汞柱，直立位血压降低24/14毫米汞柱。治疗4周后，服药12小时，非洛地平使仰卧位血压降低11/8毫米汞柱，直立位血压降低16/8毫米汞柱；硝苯地平使仰卧位血压降低3/2毫米汞柱，直立位血压降低6/4毫米汞柱。2例服用硝苯地平的患者因不良反应退出研究。然而，总体而言，副作用较少，两种药物之间无显著差异。
