Sulyok E, Seri I, Tulassay T, Kiszel J, Ertl T
Eur J Pediatr. 1985 Jan;143(3):191-3. doi: 10.1007/BF00442135.
Nine premature infants with birth weight of 1150 to 2500 g and gestational age of 28 to 35 weeks were given dopamine in a dose of 2-4 micrograms/kg/min to treat cardiopulmonary distress. In addition to monitoring of blood gases, blood pressure, acid-base balance, urine flow and urinary sodium excretion, plasma renin activity (PRA) and plasma aldosterone concentration (PA) was also determined prior to and during dopamine therapy. The dopamine-induced increase in urine flow and urinary sodium excretion was associated with a significant increase of PRA from 18.2 +/- 5.1 ng/ml/h to 33.0 +/- 5.6 ng/ml/h (P less than 0.025), while PA and blood pressure remained unaltered by dopamine administration. It is suggested that the angiotensin II-stimulated aldosterone production is overridden by the inhibitory effect of dopamine.
9名出生体重为1150至2500克、胎龄为28至35周的早产儿接受了剂量为2至4微克/千克/分钟的多巴胺治疗，以治疗心肺窘迫。除监测血气、血压、酸碱平衡、尿量和尿钠排泄外，还在多巴胺治疗前和治疗期间测定了血浆肾素活性（PRA）和血浆醛固酮浓度（PA）。多巴胺引起的尿量和尿钠排泄增加与PRA从18.2±5.1纳克/毫升/小时显著增加至33.0±5.6纳克/毫升/小时有关（P<0.025），而给予多巴胺后PA和血压未发生改变。提示多巴胺的抑制作用超过了血管紧张素II刺激的醛固酮生成作用。
