School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, U.K.
Biochem Soc Trans. 2024 Jun 26;52(3):1539-1548. doi: 10.1042/BST20240450.
Mitochondria are essential organelles of eukaryotic cells and thus mitochondrial proteome is under constant quality control and remodelling. Yme1 is a multi-functional protein and subunit of the homo-hexametric complex i-AAA proteinase. Yme1 plays vital roles in the regulation of mitochondrial protein homeostasis and mitochondrial plasticity, ranging from substrate degradation to the regulation of protein functions involved in mitochondrial protein biosynthesis, energy production, mitochondrial dynamics, and lipid biosynthesis and signalling. In this mini review, we focus on discussing the current understanding of the roles of Yme1 in mitochondrial protein import via TIM22 and TIM23 pathways, oxidative phosphorylation complex function, as well as mitochondrial lipid biosynthesis and signalling, as well as a brief discussion of the role of Yme1 in modulating mitochondrial dynamics.
线粒体是真核细胞的必需细胞器，因此线粒体蛋白质组处于持续的质量控制和重塑之中。Yme1 是一种多功能蛋白，也是同六聚体 i-AAA 蛋白酶复合物的亚基。Yme1 在调节线粒体蛋白质稳态和线粒体可塑性方面发挥着重要作用，范围从底物降解到调节参与线粒体蛋白质生物合成、能量产生、线粒体动力学以及脂质生物合成和信号转导的蛋白质功能。在这篇迷你综述中，我们重点讨论了 Yme1 在 TIM22 和 TIM23 途径中线粒体蛋白导入、氧化磷酸化复合物功能以及线粒体脂质生物合成和信号转导中的作用的最新认识，并简要讨论了 Yme1 在调节线粒体动力学中的作用。
