Bacterial and viral serology laboratory, Institut Pasteur, Abidjan, Ivory Coast.
Unité "Organisation nucléaire et oncogenèse", INSERM U993, Institut Pasteur, Paris, France.
J Infect Dev Ctries. 2024 May 30;18(5):679-686. doi: 10.3855/jidc.17675.
Few studies on SARS-CoV-2 seroprevalence in Ivory Coast have been conducted since the first case was reported on March 11, 2020. The main objective of this study was to observe and better understand the circulation of SARS-CoV-2 in Abidjan.
This prospective study collected data concerning age, sex, vaccination status, municipality of origin, monthly income, frequency of malaria, and frequency of diarrheal diseases in persons who gave their informed consent. Venous blood samples were taken to test for anti-SARS-COV-2 antibodies (IgM and IgG) using the VIDAS automated system.
A total of 1504 patients were recruited and tested for antibodies directed against SARS-COV-2. Data analysis revealed the presence of anti-SARS-CoV-2 in 53.5% of participants, 17.3% of the participants had a previous symptomatic infection, 31.4% had an asymptomatic infection, and 44.8% were never in contact with the virus. Seroprevalence of SARS-CoV-2 was higher in Marcory (70.9%) and Cocody (61.1%) than in the remaining townships (48.4%). Township rates of serologically confirmed SARS-CoV-2 infection correlated with poverty index (p = 0.025), children < 5 years' proportion in the township (p = 0.026), and levels of malaria (p = 0.034).
In the city of Abidjan, COVID-19 is strongly modulated by poverty, the proportion of babies and toddlers in the community, or exposure to malaria.
自 2020 年 3 月 11 日报告首例病例以来，科特迪瓦对 SARS-CoV-2 血清流行率的研究甚少。本研究的主要目的是观察和更好地了解 SARS-CoV-2 在阿比让的传播情况。
这项前瞻性研究收集了年龄、性别、疫苗接种状况、原籍市、月收入、疟疾频率和腹泻病频率等数据，这些数据是在知情同意的情况下收集的。采集静脉血样，使用 VIDAS 自动化系统检测针对 SARS-COV-2 的抗体（IgM 和 IgG）。
共招募并检测了 1504 名患者的 SARS-CoV-2 抗体。数据分析显示，53.5%的参与者体内存在抗 SARS-CoV-2 抗体，17.3%的参与者曾有过症状性感染，31.4%的参与者为无症状感染，44.8%的参与者从未接触过病毒。马科里（70.9%）和科科迪（61.1%）的 SARS-CoV-2 血清流行率高于其余城镇（48.4%）。血清学确认的 SARS-CoV-2 感染的城镇率与贫困指数（p = 0.025）、城镇中 5 岁以下儿童比例（p = 0.026）和疟疾水平（p = 0.034）相关。
在阿比让市，COVID-19 受到贫困、社区中婴儿和幼儿的比例或疟疾暴露的强烈调节。
