State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, People's Republic of China; Joint Research Center for Food Nutrition and Health of IHM, Hefei, Anhui 230036, People's Republic of China.
State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, People's Republic of China.
Food Chem. 2024 Oct 30;456:139936. doi: 10.1016/j.foodchem.2024.139936. Epub 2024 Jun 6.
Large-leaf yellow tea (LYT)-derived peptides (TPP) are rich in amino acids required for damage repair, such as Glu, Arg, and Pro, and can be used to alleviate acute colitis. However, its effect and mechanisms against colitis remain unclear. This study utilized TPP to intervene in dextran sodium sulfate-induced acute colitis in C57BL/6 J mice. Results confirmed that TPP ameliorated acute colitis symptoms by inhibiting pro-inflammatory cytokines, restoring gut microbiota dysbiosis, particularly by increasing the abundance of beneficial bacteria Akkermansia and Lactobacillus while declining harmful microbiota Escherichia-Shigella. Besides, TPP intervention reshaped the gut microbiota phenotype by increasing the aerobic phenotype and reducing the potentially pathogenic phenotype. Levels of short-chain fatty acids, including acetic acid, propanoic acid, isobutyric acid, and butyric acid, were also enhanced in a dose-dependent manner to help restore gut microbiota equilibrium. This study supports using TPP as a viable plant protein-derived dietary resource for alleviating inflammatory bowel disease.
大叶黄花茶衍生肽（TPP）富含损伤修复所需的氨基酸，如 Glu、Arg 和 Pro，可用于缓解急性结肠炎。然而，其对抗结肠炎的作用和机制尚不清楚。本研究利用 TPP 干预葡聚糖硫酸钠诱导的 C57BL/6J 小鼠急性结肠炎。结果证实，TPP 通过抑制促炎细胞因子、恢复肠道微生物失调来改善急性结肠炎症状，特别是通过增加有益菌 Akkermansia 和 Lactobacillus 的丰度，同时降低有害菌 Escherichia-Shigella 的丰度。此外，TPP 干预通过增加需氧表型和减少潜在致病性表型来重塑肠道微生物群表型。短链脂肪酸（包括乙酸、丙酸、异丁酸和丁酸）的水平也呈剂量依赖性增加，有助于恢复肠道微生物群平衡。本研究支持将 TPP 作为一种可行的植物蛋白衍生膳食资源，用于缓解炎症性肠病。
