Wang Diandian, Zhou Yaxi, Zhao Jian, Ren Chao, Yan Wenjie
College of Biochemical Engineering, Beijing Union University, Beijing 100023, China.
Beijing Key Laboratory of Bioactive Substances and Functional Food, Beijing Union University, Beijing 100023, China.
Foods. 2024 Aug 21;13(16):2621. doi: 10.3390/foods13162621.
Excessive UV exposure can lead to skin roughness, wrinkles, pigmentation, and reduced elasticity, with severe cases potentially causing skin cancer. Nowadays, various anti-photoaging strategies have been developed to maintain skin health. Among them, dietary supplements with anti-photoaging properties are gaining increasing attention. Yak whey protein (YWP) possesses multiple benefits, including anti-inflammatory, antioxidant, and immune-boosting properties, effectively protecting the skin. This study used a mixed UVA and UVB light source to irradiate a nude mouse model, exploring the advantages of YWP in anti-photoaging and regulating gut microbiota. The results indicated that YWP alleviated UV-induced skin damage, wrinkles, dryness, and reduced elasticity by inhibiting oxidative stress, inflammatory factors (IL-1α, IL-6, and TNF-α), and matrix metalloproteinases (MMP-1, MMP-3, and MMP-12), thereby increasing the levels of elastin, type I collagen, and type III collagen in the extracellular matrix (ECM). Additionally, YWP significantly improved the abundance of and in the gut microbiota of mice, promoting the growth of beneficial bacteria such as , , and , mitigating the dysbiosis caused by photoaging. These findings underscore the potential of YWP in anti-photoaging and gut microbiota improvement, highlighting it as a promising functional food for enhancing skin and gut health.
过度暴露于紫外线会导致皮肤粗糙、出现皱纹、色素沉着和弹性降低，严重时可能引发皮肤癌。如今，人们已开发出各种抗光老化策略来维持皮肤健康。其中，具有抗光老化特性的膳食补充剂越来越受到关注。牦牛奶清蛋白（YWP）具有多种益处，包括抗炎、抗氧化和增强免疫力，能有效保护皮肤。本研究使用混合的紫外线A和紫外线B光源照射裸鼠模型，探究YWP在抗光老化和调节肠道微生物群方面的优势。结果表明，YWP通过抑制氧化应激、炎症因子（IL-1α、IL-6和TNF-α）和基质金属蛋白酶（MMP-1、MMP-3和MMP-12），减轻了紫外线诱导的皮肤损伤、皱纹、干燥和弹性降低，从而增加了细胞外基质（ECM）中弹性蛋白、I型胶原蛋白和III型胶原蛋白的水平。此外，YWP显著改善了小鼠肠道微生物群中 和 的丰度，促进了诸如 、 和 等有益细菌的生长，减轻了光老化引起的生态失调。这些发现强调了YWP在抗光老化和改善肠道微生物群方面的潜力，突出其作为一种有望促进皮肤和肠道健康的功能性食品的地位。
