College of Life Sciences, Fujian Normal University, Fuzhou 350117, PR China; Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, Fujian Normal University, Fuzhou 350117, PR China.
Fujian Inspection and Research Institute for Product Quality, Fuzhou 350117, PR China.
Bioorg Chem. 2024 Sep;150:107505. doi: 10.1016/j.bioorg.2024.107505. Epub 2024 May 29.
Nitric oxide (NO) plays an important role in multiple physiological processes of the body involved in regulation, such as cardiovascular relaxation, neural homeostasis, and immune regulation, etc. The real-time monitoring of NO is of great significance in the investigation of related disease mechanisms and the evaluation of pharmacodynamics. Fluorescent probes are considered as a highly promising approach for pharmaceutical analysis and bioimaging due to their non-invasive character, real-time detection, and high sensitivity. However, there are still some challenges in the determination of biological nitric oxide with fluorescent probes, such as low anti-interference ability, poor function modifiability, and low organ specificity. Therefore, it would be beneficial to develop a new generation of fluorescent probes for real-time bioimaging of NO in vivo after this systematic summary.
一氧化氮（NO）在参与调节的身体的多种生理过程中发挥着重要作用，如心血管松弛、神经内稳态和免疫调节等。实时监测 NO 在研究相关疾病机制和评价药效动力学方面具有重要意义。荧光探针由于其非侵入性、实时检测和高灵敏度等特点，被认为是药物分析和生物成像的一种很有前途的方法。然而，在使用荧光探针测定生物一氧化氮时，仍然存在一些挑战，如抗干扰能力低、功能修饰性差、器官特异性低等。因此，在对其进行系统总结后，开发新一代用于体内一氧化氮实时生物成像的荧光探针将是有益的。
