Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China; Botany Department, Faculty of Science, Tanta University, Tanta 31527, Egypt.
Department of Prosthodontics, College of Dentistry, University of Baghdad, Baghdad, Iraq; Branch of Prosthodontics, College of Dentistry, University of Al-Ameed, Karbala, Iraq.
Int J Biol Macromol. 2024 Jul;273(Pt 2):132986. doi: 10.1016/j.ijbiomac.2024.132986. Epub 2024 Jun 10.
As a unique natural resource, fungi are a sustainable source of lipids, polysaccharides, vitamins, proteins, and other nutrients. As a result, they have beneficial medicinal and nutritional properties. Polysaccharides are among the most significant bioactive components found in fungi. Increasing research has revealed that fungal polysaccharides (FPS) contain a variety of bioactivities, including antitumor, antioxidant, immunomodulatory, anti-inflammatory, hepatoprotective, cardioprotective, and anti-aging properties. However, the exact knowledge about FPS and their applications related to their future possibilities must be thoroughly examined to enhance a better understanding of this sustainable biopolymer source. Therefore, FPS' biological applications and their role in the food and feed industry, agriculture, and cosmetics applications were all discussed in this work. In addition, this review highlighted the mode of action of FPS on human diseases by regulating gut microbiota and discussed the mechanism of FPS as antioxidants in the living cell. The structure-activity connections of FPS were also highlighted and explored. Moreover, future perspectives were listed to pave the way for future studies of FPS applications. Hence, this study can be a scientific foundation for future FPS research and industrial applications.
作为一种独特的自然资源，真菌是脂质、多糖、维生素、蛋白质和其他营养物质的可持续来源。因此，它们具有有益的药用和营养价值。多糖是真菌中最主要的生物活性成分之一。越来越多的研究表明，真菌多糖（FPS）具有多种生物活性，包括抗肿瘤、抗氧化、免疫调节、抗炎、保肝、护心和抗衰老特性。然而，要想充分了解这种可持续生物聚合物的来源，就必须深入研究 FPS 的确切知识及其与未来可能性相关的应用。因此，本文讨论了 FPS 在食品和饲料工业、农业和化妆品应用中的生物应用及其作用。此外，本文还通过调节肠道微生物群来强调 FPS 对人类疾病的作用方式，并讨论了 FPS 作为活细胞中抗氧化剂的作用机制。还强调和探讨了 FPS 的结构-活性关系。此外，还列出了未来的展望，为未来 FPS 的应用研究铺平了道路。因此，本研究可为未来 FPS 的研究和工业应用提供科学基础。
