Institute of Natural Medicine, University of Toyama.
Faculty of Science, Gakushuin University.
Chem Pharm Bull (Tokyo). 2024;72(6):540-546. doi: 10.1248/cpb.c24-00240.
Three neo-clerodane diterpenoids, including two new tinocordifoliols A (1) and B (2) and one known tinopanoid R (3), were isolated from the ethyl acetate-soluble fraction of the 70% ethanol extract of Tinospora cordifolia stems. The structures were elucidated by various spectroscopic methods, including one dimensional (1D) and 2D-NMR, high resolution-electrospray ionization (HR-ESI)-MS, and electronic circular dichroism (ECD) data. The T. cordifolia extract and all isolated compounds 1-3 possessed arginase I inhibitory activities. Among them, 3 exhibited moderate competitive inhibition of human arginase I (IC = 61.9 µM). Furthermore, docking studies revealed that the presence of a β-substituted furan in 3 may play a key role in the arginase I inhibitory activities.
从三叶崖爬藤茎的 70%乙醇提取物的乙酸乙酯可溶部分中分离得到了三种新的 neo- clerodane 二萜类化合物，包括两个新的锡诺考福醇 A（1）和 B（2）以及一个已知的锡诺潘诺 R（3）。通过各种光谱方法，包括一维（1D）和二维 NMR、高分辨率电喷雾电离（HR-ESI）-MS 和电子圆二色性（ECD）数据，确定了这些化合物的结构。三叶崖爬藤提取物和所有分离得到的化合物 1-3 都具有精氨酸酶 I 抑制活性。其中，化合物 3 对人精氨酸酶 I 表现出中等强度的竞争性抑制作用（IC = 61.9 µM）。此外，对接研究表明，化合物 3 中β-取代的呋喃的存在可能在精氨酸酶 I 抑制活性中起关键作用。
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