甘油三酯葡萄糖指数与糖尿病患者的全因死亡率呈非线性相关。

The triglyceride glucose index was nonlinearly associated with all-cause mortality in diabetic patients.

机构信息

Department of Cardiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310000, China; The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310000, China.

The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310000, China.

出版信息

Nutr Metab Cardiovasc Dis. 2024 Aug;34(8):2012-2015. doi: 10.1016/j.numecd.2024.04.009. Epub 2024 Apr 26.

DOI:10.1016/j.numecd.2024.04.009

PMID:38866610

Abstract

BACKGROUND AND AIM

The TyG index has been linked with cardiometabolic diseases. Our study aimed to investigate the specific relationship between the triglyceride and glucose index (TyG) and both all-cause and cardiovascular mortality in diabetic patients.

METHODS AND RESULTS

We enrolled 3120 participants with diabetes from the National Health and Nutrition Examination Survey. The TyG index was calculated using the formula ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Hazard ratios (HRs) of TyG associated with mortality risk were assessed using Cox proportional hazard regression models. Over a follow-up period of 10.8 thousand person-years, we observed 768 all-cause deaths and 155 cardiovascular deaths. Compared to the reference quartile, the multivariate-adjusted hazard ratios and 95% confidence intervals for all-cause mortality were 1.02 (1.01-1.05; p = 0.008) in the fourth quartile. Dose-response analysis revealed a non-linear association. However, no significant associations were found between the TyG index and cardiovascular mortality.

CONCLUSIONS

The TyG index exhibited a non-linear association with the risk of all-cause mortality in diabetic patients.

摘要

背景与目的

甘油三酯和葡萄糖指数（TyG）与心脏代谢疾病有关。本研究旨在探讨 TyG 指数与糖尿病患者全因和心血管死亡率之间的具体关系。

方法和结果

我们纳入了来自全国健康和营养检查调查的 3120 名糖尿病患者。TyG 指数通过公式 ln [空腹甘油三酯（mg/dL）×空腹血糖（mg/dL）/2] 计算。使用 Cox 比例风险回归模型评估 TyG 与死亡风险相关的风险比（HRs）。在 10.8 千人人年的随访期间，我们观察到 768 例全因死亡和 155 例心血管死亡。与参考四分位数相比，全因死亡率的多变量调整 HR 及其 95%置信区间在第四四分位数为 1.02（1.01-1.05；p=0.008）。剂量反应分析显示出非线性关联。然而，TyG 指数与心血管死亡率之间没有显著关联。