Institut Pasteur, Mitochondrial Biology, CNRS UMR 3691, Université Paris Cité, Paris, France.
Trends Endocrinol Metab. 2024 Oct;35(10):854-871. doi: 10.1016/j.tem.2024.05.005. Epub 2024 Jun 11.
Mitochondria are double membrane-bound organelles the network morphology of which in cells is shaped by opposing events of fusion and fission executed by dynamin-like GTPases. Mutations in these genes can perturb the form and functions of mitochondria in cell and animal models of mitochondrial diseases. An expanding array of chemical, mechanical, and genetic stressors can converge on mitochondrial-shaping proteins and disrupt mitochondrial morphology. In recent years, studies aimed at disentangling the multiple roles of mitochondrial-shaping proteins beyond fission or fusion have provided insights into the homeostatic relevance of mitochondrial morphology. Here, I review the pleiotropy of mitochondrial fusion and fission proteins with the aim of understanding whether mitochondrial morphology is important for cell and tissue physiology.
线粒体是双层膜结合的细胞器，其在细胞中的网络形态由动力蛋白样 GTP 酶执行的融合和裂变的相反事件形成。这些基因的突变会扰乱线粒体疾病的细胞和动物模型中线粒体的形态和功能。越来越多的化学、机械和遗传应激源可以集中在塑造线粒体的蛋白质上，并破坏线粒体的形态。近年来，旨在阐明线粒体成形蛋白除了分裂或融合之外的多种作用的研究，为线粒体形态的稳态相关性提供了新的认识。在这里，我回顾了线粒体融合和裂变蛋白的多效性，目的是了解线粒体形态对细胞和组织生理学是否重要。
