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减肥干预对肥胖症合并多囊卵巢综合征女性焦虑、抑郁和生活质量的影响。

Effects of weight loss intervention on anxiety, depression and quality of life in women with severe obesity and polycystic ovary syndrome.

机构信息

Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 430, 405 30, Gothenburg, Sweden.

Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Gothenburg, Sweden.

出版信息

Sci Rep. 2024 Jun 12;14(1):13495. doi: 10.1038/s41598-024-63166-w.

DOI:10.1038/s41598-024-63166-w

PMID:38866860

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11169487/

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women that is associated with an increased risk of anxiety and depression and with a lower health-related quality of life (HRQoL). PCOS is closely associated with obesity, which per se can lead to symptoms of anxiety and depression and lower HRQoL. The first-line treatment for PCOS is weight loss through lifestyle intervention, which has been shown to improve all symptoms of the syndrome. The aim of this study was to investigate symptoms of anxiety and depression and HRQoL in women with severe obesity (BMI ≥ 35) with and without PCOS, and to evaluate the effect of a one-year structured weight loss intervention. A total of 246 women with severe obesity (PCOS n = 63, non-PCOS n = 183) were included. The comprehensive psychopathological rating scale self-rating scale for affective symptoms (CPRS-S-A) and the short form-36 (SF-36) were used to assess symptoms of anxiety and depression and HRQoL. In total 72 women of the 246 women with severe obesity completed a one-year weight loss programme and were followed up and compared with baseline data. In women with severe obesity, there were no differences in symptoms of anxiety and depression and HRQoL between women with and without PCOS at baseline. Clinically relevant anxiety symptoms were present in 71.3% (PCOS) and 65.6% (non-PCOS), and depression symptoms were present in 56.4% (PCOS) and 52.2% (non-PCOS). Significant weight loss improved physical HRQoL in all women, but reduced symptoms of anxiety and depression only in women without PCOS. There were no differences when comparing the changes between the groups. Women with severe obesity are severely affected by symptoms of anxiety and depression, independent of PCOS. Weight loss improved symptoms of anxiety and depression in women without PCOS, but there were no differences between groups in change from baseline to follow-up.Trial registration number: Clinical trial.gov: NCT01319162, March 18, 2011. Date of registration and enrolment of the first subject September 2011.

摘要

多囊卵巢综合征（PCOS）是一种常见的女性内分泌疾病，与焦虑和抑郁风险增加以及健康相关生活质量（HRQoL）降低有关。PCOS 与肥胖密切相关，肥胖本身可导致焦虑和抑郁症状，并降低 HRQoL。PCOS 的一线治疗方法是通过生活方式干预减轻体重，这已被证明可以改善该综合征的所有症状。本研究旨在调查患有严重肥胖症（BMI≥35）的女性中伴有和不伴有 PCOS 的焦虑和抑郁症状以及 HRQoL，并评估为期一年的结构化减肥干预的效果。共纳入 246 名患有严重肥胖症的女性（PCOS 组 n=63，非 PCOS 组 n=183）。使用综合精神病理学评定量表自评情感症状量表（CPRS-S-A）和简明健康状况调查问卷 36 项版（SF-36）评估焦虑和抑郁症状及 HRQoL。共有 246 名患有严重肥胖症的女性中的 72 名完成了为期一年的减肥计划，并进行了随访并与基线数据进行了比较。在患有严重肥胖症的女性中，无论是否患有 PCOS，基线时的焦虑和抑郁症状以及 HRQoL 均无差异。71.3%（PCOS）和 65.6%（非 PCOS）的女性存在明显的焦虑症状，56.4%（PCOS）和 52.2%（非 PCOS）的女性存在抑郁症状。所有女性的体重显著减轻都改善了身体 HRQoL，但仅在没有 PCOS 的女性中减轻了焦虑和抑郁症状。组间比较时，没有差异。患有严重肥胖症的女性受到焦虑和抑郁症状的严重影响，与 PCOS 无关。减肥改善了无 PCOS 女性的焦虑和抑郁症状，但从基线到随访的变化在组间没有差异。试验注册号：Clinicaltrials.gov：NCT01319162，2011 年 3 月 18 日。首个入组受试者登记日期和时间为 2011 年 9 月。