肥胖多囊卵巢综合征女性与对照组健康相关生活质量受减肥影响的研究。

The effects of weight loss on health-related quality of life in obese women with PCOS and controls.

机构信息

Department of Midwifery, Faculty of Nursing and Midwifery, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

BMC Womens Health. 2023 Oct 10;23(1):532. doi: 10.1186/s12905-023-02682-9.

DOI:10.1186/s12905-023-02682-9

PMID:37817138

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10566153/

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is a complicated endocrine disorder with widespread symptoms that reduce women's quality of life. The adverse effect of associated obesity on this reduction is unclear, therefore the impact of weight loss on health-related quality of life (HRQOL) in obese women with PCOS is unknown. This study aimed to compare the impact of weight loss following a 24-week dietary intervention on HRQOL in obese women with and without PCOS.

METHODS

In a 24-week hypocaloric LGI (low glycemic index) diet intervention study, 286 women were recruited (140 PCOS, 146 controls) and 216 participants (PCOS = 105, non-PCOS = 111) completed the study. HRQOL was assessed using the SF-36 questionnaire (Short Form Health Survey). Physical activity was measured using the short form of the International Physical Activity Questionnaire (IPAQ). Anthropometric assessments, dietary intake, physical activity levels, and HRQOL scores, according to the Iranian version of SF-36, were compared at baseline and 24 weeks with intervention.

RESULTS

At the end of the intervention, there was no significant difference in the percentages of weight loss between the two groups (PCOS: 6.29 ± 3.32% vs. non-PCOS: 7 ± 3.62%, p = 0.1). At baseline, women with PCOS had lower mean scores in aspects of physical function (PF), general health perception (GH), role limitation due to emotional problem (RE), vitality (VT), mental health (MH), physical (PCS) and mental component summary scales (MCS), compared to non-PCOS (P < 0.01). At 24 weeks, the percentage of improvement in HRQOL in the non-PCOS group was higher compared to the PCOS group but this difference didn't reach statistical significance except for PCS. In both groups, greater weight loss was associated with further improvement in the physical aspects of HRQOL and vitality. In the non-PCOS group, with trivial exception, greater weight loss was associated with greater improvement in the mental aspects of HRQOL.

CONCLUSIONS

Both obese PCOS and non-PCOS women achieved nearly similar levels of improvement in HRQOL due to weight loss induced by a hypocaloric LGI diet.

TRIAL REGISTRATION

This study is registered in the Iranian Randomized Clinical Trials Registry (IRCT, code: IRCT2016092129909N1).

摘要

背景

多囊卵巢综合征（PCOS）是一种复杂的内分泌疾病，具有广泛的症状，降低了女性的生活质量。相关肥胖对这种降低的不利影响尚不清楚，因此肥胖 PCOS 妇女体重减轻对健康相关生活质量（HRQOL）的影响尚不清楚。本研究旨在比较 24 周低热量低升糖指数（LGI）饮食干预后体重减轻对肥胖 PCOS 和非 PCOS 妇女 HRQOL 的影响。

方法

在一项为期 24 周的低热量 LGI 饮食干预研究中，招募了 286 名女性（140 名 PCOS，146 名对照组），216 名参与者完成了研究（PCOS=105，非 PCOS=111）。使用 SF-36 问卷（健康调查简表）评估 HRQOL。使用国际体力活动问卷（IPAQ）的简短形式测量体力活动。根据伊朗版 SF-36，在基线和 24 周干预时比较人体测量评估、膳食摄入量、体力活动水平和 HRQOL 评分。

结果

干预结束时，两组体重减轻的百分比无显著差异（PCOS：6.29%±3.32%vs.非 PCOS：7%±3.62%，p=0.1）。基线时，与非 PCOS 组相比，PCOS 组的身体功能（PF）、一般健康感知（GH）、情绪问题所致角色限制（RE）、活力（VT）、心理健康（MH）、身体（PCS）和精神成分综合量表（MCS）的平均得分较低（P<0.01）。24 周时，与 PCOS 组相比，非 PCOS 组的 HRQOL 改善百分比更高，但除 PCS 外，差异无统计学意义。在两组中，体重减轻越多，与 HRQOL 身体方面和活力的进一步改善相关。在非 PCOS 组中，除了微不足道的例外，体重减轻与心理健康方面的改善更大相关。