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Colorectal cancer clocks in on TIME.

作者信息

Knudsen-Clark Amelia M, Altman Brian J

机构信息

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, USA.

出版信息

Nat Immunol. 2024 Jul;25(7):1133-1135. doi: 10.1038/s41590-024-01874-1.

DOI:10.1038/s41590-024-01874-1
PMID:38866973
Abstract
摘要

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Circadian control of tumor immunosuppression affects efficacy of immune checkpoint blockade.昼夜节律控制肿瘤免疫抑制影响免疫检查点阻断的疗效。
Nat Immunol. 2024 Jul;25(7):1257-1269. doi: 10.1038/s41590-024-01859-0. Epub 2024 May 28.
2
Myeloid-derived suppressor cells in cancer and cancer therapy.髓源性抑制细胞在癌症和癌症治疗中的作用。
Nat Rev Clin Oncol. 2024 Feb;21(2):147-164. doi: 10.1038/s41571-023-00846-y. Epub 2024 Jan 8.
3
Association of circadian timing of initial infusions of immune checkpoint inhibitors with survival in advanced melanoma.
生物钟时机与晚期黑色素瘤免疫检查点抑制剂初始输注生存的关联。
Immunotherapy. 2023 Aug;15(11):819-826. doi: 10.2217/imt-2022-0139. Epub 2023 May 16.
4
Cancer statistics, 2023.癌症统计数据，2023 年。
CA Cancer J Clin. 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763.
5
Dendritic cells direct circadian anti-tumour immune responses.树突状细胞指导昼夜节律抗肿瘤免疫反应。
Nature. 2023 Feb;614(7946):136-143. doi: 10.1038/s41586-022-05605-0. Epub 2022 Dec 5.
6
Disruption of the circadian clock drives loss of heterozygosity to accelerate colorectal cancer.昼夜节律钟的破坏导致杂合性丢失，从而加速结直肠癌的发生。
Sci Adv. 2022 Aug 12;8(32):eabo2389. doi: 10.1126/sciadv.abo2389. Epub 2022 Aug 10.
7
Time-Dependent Efficacy of Checkpoint Inhibitor Nivolumab: Results from a Pilot Study in Patients with Metastatic Non-Small-Cell Lung Cancer.检查点抑制剂纳武单抗的时间依赖性疗效：转移性非小细胞肺癌患者的一项初步研究结果
Cancers (Basel). 2022 Feb 11;14(4):896. doi: 10.3390/cancers14040896.
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Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice.肿瘤相关巨噬细胞 PD-1 的昼夜表达是 PD-1/PD-L1 抑制剂 BMS-1 在 B16/BL6 黑色素瘤荷瘤小鼠中剂量依赖性抗肿瘤作用的基础。
Mol Cancer Res. 2022 Jun 3;20(6):972-982. doi: 10.1158/1541-7786.MCR-21-0786.
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Effect of immunotherapy time-of-day infusion on overall survival among patients with advanced melanoma in the USA (MEMOIR): a propensity score-matched analysis of a single-centre, longitudinal study.美国晚期黑色素瘤患者免疫疗法日间输注时间对总生存期的影响（MEMOIR）：一项单中心纵向研究的倾向评分匹配分析。
Lancet Oncol. 2021 Dec;22(12):1777-1786. doi: 10.1016/S1470-2045(21)00546-5. Epub 2021 Nov 12.
10
Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation.昼夜节律紊乱促进肿瘤免疫微环境重塑，有利于肿瘤细胞增殖。
Sci Adv. 2020 Oct 14;6(42). doi: 10.1126/sciadv.aaz4530. Print 2020 Oct.