Li Jiazhen, Ma Zhijun, Ma Deshou, Maimaiti Yusufu, Jiang Shuyun, Wang Xiaowu
Department of Surgical Oncology, The Affiliated Hospital of Qinghai University, Xining, Qinghai Province, China.
Department of Clinical Medicine, Qinghai University, Xining, Qinghai Province, China.
BMC Endocr Disord. 2024 Jun 12;24(1):87. doi: 10.1186/s12902-024-01617-1.
Anaplastic thyroid carcinoma(ATC) is a rare pathological type of thyroid malignancy. Primary squamous cell carcinoma of thyroid(PSCCT) is now considered as a subtype of ATC, hereinafter referred to as ATC-SCC subtype. ATC-SCC subtype combined with follicular thyroid carcinoma is exceedingly rare, with fewer cases reported. The ATC-SCC subtype is a highly invasive tumor with a poor prognosis for patients after metastasis occurs, and current treatment of this type of tumor is tricky.
A 68-year-old female patient presented with a gradually growing swelling of right cervical region. Comprehensive auxiliary examinations and postoperative pathology confirmed the diagnosis of ATC-SCC subtype with follicular thyroid carcinoma, and the metastasis squamous cell carcinoma of the right cervical lymph nodes originates from ATC-SCC subtype. The patient received chemoradiotherapy postoperative. However, the residual cervical lymph nodes metastasis with squamous cell carcinoma still infiltrated surrounding structures in the neck extensively after palliative resection. The patient died 7 months after surgery.
Our case highlights that cervical lymph node metastasis may be a significant factor in the poor prognosis of ATC-SCC subtype. This malignancy should be detected and treated early.
间变性甲状腺癌（ATC）是一种罕见的甲状腺恶性肿瘤病理类型。甲状腺原发性鳞状细胞癌（PSCCT）现被视为ATC的一种亚型，以下简称ATC-SCC亚型。ATC-SCC亚型合并滤泡状甲状腺癌极为罕见，报道的病例较少。ATC-SCC亚型是一种侵袭性很强的肿瘤，转移发生后患者预后较差，目前针对这类肿瘤的治疗颇具难度。
一名68岁女性患者出现右颈部逐渐增大的肿物。综合辅助检查及术后病理确诊为ATC-SCC亚型合并滤泡状甲状腺癌，右颈部淋巴结转移的鳞状细胞癌起源于ATC-SCC亚型。患者术后接受了放化疗。然而，姑息性切除术后，残留的颈部淋巴结鳞状细胞癌转移灶仍广泛浸润颈部周围结构。患者术后7个月死亡。
我们的病例表明，颈部淋巴结转移可能是ATC-SCC亚型预后不良的一个重要因素。这种恶性肿瘤应尽早发现并治疗。
