Deng An-Fu, Wang Fu-Xiao, Wang Si-Cheng, Zhang Ying-Ze, Bai Long, Su Jia-Can
Institute of Translational Medicine, Organoid Research Center, Shanghai University, Shanghai, 200444, China.
National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China.
Mil Med Res. 2024 Jun 12;11(1):37. doi: 10.1186/s40779-024-00540-9.
In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various organs by secreting specific cytokines (also known as osteokines). This reciprocal influence extends to these organs modulating bone homeostasis and development, although this aspect has yet to be systematically reviewed. This review aims to elucidate this bidirectional crosstalk, with a particular focus on the role of osteokines. Additionally, it presents a unique compilation of evidence highlighting the critical function of extracellular vesicles (EVs) within bone-organ axes for the first time. Moreover, it explores the implications of this crosstalk for designing and implementing bone-on-chips and assembloids, underscoring the importance of comprehending these interactions for advancing physiologically relevant in vitro models. Consequently, this review establishes a robust theoretical foundation for preventing, diagnosing, and treating diseases related to the bone-organ axis from the perspective of cytokines, EVs, hormones, and metabolites.
除了在提供结构支持方面的公认作用外，骨骼通过分泌特定的细胞因子（也称为骨源因子）在维持各种器官的功能和平衡方面发挥着关键作用。这种相互影响延伸到这些器官对骨稳态和发育的调节，尽管这方面尚未得到系统综述。本综述旨在阐明这种双向串扰，特别关注骨源因子的作用。此外，它首次呈现了一系列独特的证据，突出了细胞外囊泡（EVs）在骨-器官轴内的关键功能。此外，它探讨了这种串扰对骨芯片和组装体设计与实施的影响，强调了理解这些相互作用对于推进生理相关体外模型的重要性。因此，本综述从细胞因子、EVs、激素和代谢物的角度为预防、诊断和治疗与骨-器官轴相关的疾病奠定了坚实的理论基础。
